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PECAM-1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249213

CD31 (PECAM1) is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. CD31 is a member of the immunoglobulin superfamily and is likely involved in… More details

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Product Overview

Product Name
PECAM-1 / CD31, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 4D1] (IgG1) to Human PECAM-1 / CD31
Product Gene Name
anti-PECAM-1 antibody
Product Synonym Gene Name
CD31
Product Synonym Names
Anti-PECAM-1 / CD31 Antibody (clone 4D1) IHC-plus; PECAM1; CD31; CD31 antigen; EndoCAM; PECA1; PECAM-1; GPIIA; Human PECAM-1; CD31
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4D1
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Protein A/G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human CD31
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
81,378 Da
OMIM
173445
3D Structure
ModBase 3D Structure for P16284
Target Species
Human
Immunogen Description
Full length human recombinant protein of human PECAM1(NP_000433) produced in HEK293T cell.
Immunogen Type
Recombinant protein
Immunogen
PECAM-1 / CD31 antibody was raised against full length human recombinant protein of human PECAM1(NP_000433) produced in HEK293T cell.
Applications Tested/Suitable for anti-PECAM-1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-PECAM-1 antibody
IHC-P (10 ug/ml), WB (1:500 - 1:2000)

Immunohistochemistry (IHC) of anti-PECAM-1 antibody

Anti-PECAM-1 / CD31 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-PECAM-1 Monoclonal Antibody – Cat# MBS249213

Western Blot (WB) of anti-PECAM-1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PECAM1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PECAM1.
Mouse Anti-PECAM-1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249213

Other Notes

Small volumes of anti-PECAM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PECAM-1 purchase

MBS249213 is an antibody targeting PECAM-1. Also known as Mouse Monoclonal [clone 4D1] (IgG1) to Human PECAM-1 / CD31. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PECAM-1. It may not necessarily be applicable to this product.

NCBI GI #
110347451
NCBI GeneID
5175
NCBI Accession #
NP_000433.3
UniProt Primary Accession #
P16284
UniProt Secondary Accession #
Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; A8K3S7; D3DU31
UniProt Related Accession #
P16284
GenBank Nucleotide #
NM_000442.3
NCBI Official Full Name
platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet/endothelial cell adhesion molecule 1
NCBI Official Symbol
PECAM1
NCBI Official Synonym Symbols
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
EndoCAM; GPIIA'; PECA1; CD_antigen: CD31
UniProt Gene Name
PECAM1
UniProt Synonym Gene Names
PECAM-1
UniProt Entry Name
PECA1_HUMAN
NCBI Protein Information
platelet endothelial cell adhesion molecule; CD31 antigen

NCBI Summary for PECAM-1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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UniProt Comments for PECAM-1

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; plasma membrane; integral to membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; cell adhesion; blood coagulation; signal transduction; leukocyte migration; phagocytosis
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Research Articles on PECAM-1

1. PECAM is a sialic acid binding lectin and that this binding property supports endothelial cell survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PECAM-1 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram

Diseases associated with anti-PECAM-1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >626 publications with PECAM-1 and Cardiovascular Diseases
 Inflammation Antibodies  >498 publications with PECAM-1 and Inflammation
 Necrosis Antibodies  >403 publications with PECAM-1 and Necrosis
 Neoplasms, Experimental Antibodies  >261 publications with PECAM-1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >242 publications with PECAM-1 and Lung Diseases
 Heart Diseases Antibodies  >230 publications with PECAM-1 and Heart Diseases
 Breast Neoplasms Antibodies  >209 publications with PECAM-1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >190 publications with PECAM-1 and Lung Neoplasms
 Liver Diseases Antibodies  >174 publications with PECAM-1 and Liver Diseases
 Atherosclerosis Antibodies  >144 publications with PECAM-1 and Atherosclerosis

Organs/Tissues associated with anti-PECAM-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3415 publications with PECAM-1 and Vascular
 Blood Antibodies  >3009 publications with PECAM-1 and Blood
 Muscle Antibodies  >685 publications with PECAM-1 and Muscle
 Embryonic Tissue Antibodies  >511 publications with PECAM-1 and Embryonic Tissue
 Lung Antibodies  >435 publications with PECAM-1 and Lung
 Heart Antibodies  >351 publications with PECAM-1 and Heart
 Skin Antibodies  >340 publications with PECAM-1 and Skin
 Brain Antibodies  >324 publications with PECAM-1 and Brain
 Connective Tissue Antibodies  >245 publications with PECAM-1 and Connective Tissue
 Kidney Antibodies  >237 publications with PECAM-1 and Kidney
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