Complement C4c Antibody – Mouse Monoclonal

Monoclonal

IgG1

10-12

Mouse

Human

Borate buffered saline, 0.09% sodium azide

Protein A Purified

1 mg/ml (lot specific)

Recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonization and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kD) and alpha 3 (25 kD) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma. Binds both C4c and C4 and so is not suitable for all ELISA applications.

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Human

Purified human C4c.

Complement C4c antibody was raised against purified human C4c.