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LTA4H / LTA4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249243

LTA4H Antibody, Leukotriene A(4) hydrolase Antibody, Leukotriene A4 hydrolase Antibody, Leukotriene A-4 hydrolase Antibody, LTA-4 hydrolase Antibody, LTA4 Antibody Description: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the… More details

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Product Overview

Product Name
LTA4H / LTA4, Monoclonal Antibody
Full Product Name
Anti-LTA4H / LTA4 Antibody (clone 8F4) IHC-plus
Product Gene Name
anti-LTA4H / LTA4 antibody
Product Synonym Names
Mouse Monoclonal [clone 8F4] (IgG2a) to Human LTA4H / LTA4; Human LTA4H / LTA4; Leukotriene A(4) hydrolase; Leukotriene A4 hydrolase; Leukotriene A-4 hydrolase; LTA-4 hydrolase
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
8F4
Host
Mouse
Species Reactivity
Dog, Rat, Human
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Protein A/G purified
Concentration
1.3 mg/ml (lot specific)
Specificity
Human LTA4H / LTA4
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
66,852 Da
OMIM
151570
3D Structure
ModBase 3D Structure for P09960
Immunogen
LTA4H / LTA4 antibody was raised against protein expressed in 293T cell transfected with human LTA4H expression vector.
Immunogen Description
Protein expressed in 293T cell transfected with human LTA4H expression vector.
Immunogen Type
Transfected Cells
Target Species
Human
Applications Tested/Suitable for anti-LTA4H / LTA4 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-LTA4H / LTA4 antibody
IHC-P (1:50, 10 ug/ml)
WB (1:2000)

Immunohistochemistry - Paraffin (IHC) of anti-LTA4H / LTA4 antibody

Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-LTA4H / LTA4 Monoclonal Antibody – Cat# MBS249243

Western Blot (WB) of anti-LTA4H / LTA4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LTA4H (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LTA4H.
Mouse Anti-LTA4H / LTA4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249243

Western Blot (WB) of anti-LTA4H / LTA4 antibody

Western blot of extracts (35 ug) from 9 different cell lines by using anti-LTA4H monoclonal antibody.
Mouse Anti-LTA4H / LTA4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249243

Other Notes

Small volumes of anti-LTA4H / LTA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LTA4H / LTA4 purchase

MBS249243 is an antibody targeting LTA4H / LTA4. Also known as Anti-LTA4H / LTA4 Antibody (clone 8F4) IHC-plus. Reactive in Dog, Rat, Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LTA4H / LTA4. It may not necessarily be applicable to this product.

NCBI GI #
4505029
NCBI GeneID
4048
NCBI Accession #
NP_000886.1
UniProt Primary Accession #
P09960
UniProt Secondary Accession #
Q6IAT6; Q9UCT7; B4DNQ9; F8VV40
UniProt Related Accession #
P09960
GenBank Nucleotide #
NM_000895.2
NCBI Official Full Name
leukotriene A-4 hydrolase isoform 1
NCBI Official Synonym Full Names
leukotriene A4 hydrolase
NCBI Official Symbol
LTA4H
UniProt Protein Name
Leukotriene A-4 hydrolase
UniProt Synonym Protein Names
Leukotriene A(4) hydrolase
UniProt Gene Name
LTA4H
UniProt Synonym Gene Names
LTA4; LTA-4 hydrolase
UniProt Entry Name
LKHA4_HUMAN
NCBI Protein Information
leukotriene A-4 hydrolase

NCBI Summary for LTA4H / LTA4

The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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UniProt Comments for LTA4H / LTA4

LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Lipid Metabolism - arachidonic acid; EC 3.3.2.6

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: aminopeptidase activity; epoxide hydrolase activity; leukotriene-A4 hydrolase activity; peptidase activity; peptide binding; protein binding; zinc ion binding

Biological Process: arachidonic acid metabolic process; inflammatory response; leukotriene biosynthetic process; leukotriene metabolic process; peptide catabolic process; proteolysis; response to peptide hormone stimulus; response to zinc ion
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Research Articles on LTA4H / LTA4

1. Report no association between LTA4H SNPs and atherosclerotic plaque phenotypes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LTA4H / LTA4 antibody

 Reference Product  PubMed Publications
 ALOX5AP antibody  >20 publications with LTA4H / LTA4 and ALOX5AP
 LTC4S antibody  >17 publications with LTA4H / LTA4 and LTC4S
 LTB4R2 antibody  >2 publications with LTA4H / LTA4 and LTB4R2
 PTGR1 antibody  >2 publications with LTA4H / LTA4 and PTGR1
 CYP4F3 antibody  >1 publications with LTA4H / LTA4 and CYP4F3

Pathways associated with anti-LTA4H / LTA4 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway antibodies  Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway Diagram
 Leukotriene Biosynthesis Pathway antibodies  Leukotriene Biosynthesis Pathway Diagram
 Leukotriene Biosynthesis Pathway antibodies  Leukotriene Biosynthesis Pathway Diagram

Diseases associated with anti-LTA4H / LTA4 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >41 publications with LTA4H / LTA4 and Inflammation
 Asthma Antibodies  >19 publications with LTA4H / LTA4 and Asthma
 Nervous System Diseases Antibodies  >11 publications with LTA4H / LTA4 and Nervous System Diseases
 Atherosclerosis Antibodies  >10 publications with LTA4H / LTA4 and Atherosclerosis
 Disease Models, Animal Antibodies  >9 publications with LTA4H / LTA4 and Disease Models, Animal
 Heart Diseases Antibodies  >8 publications with LTA4H / LTA4 and Heart Diseases
 Necrosis Antibodies  >6 publications with LTA4H / LTA4 and Necrosis
 Carcinoma Antibodies  >3 publications with LTA4H / LTA4 and Carcinoma
 Hypertension Antibodies  >3 publications with LTA4H / LTA4 and Hypertension
 Fibrosis Antibodies  >2 publications with LTA4H / LTA4 and Fibrosis

Organs/Tissues associated with anti-LTA4H / LTA4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with LTA4H / LTA4 and Blood
 Lung Antibodies  >18 publications with LTA4H / LTA4 and Lung
 Vascular Antibodies  >7 publications with LTA4H / LTA4 and Vascular
 Bone Antibodies  >5 publications with LTA4H / LTA4 and Bone
 Heart Antibodies  >5 publications with LTA4H / LTA4 and Heart
 Nerve Antibodies  >4 publications with LTA4H / LTA4 and Nerve
 Muscle Antibodies  >4 publications with LTA4H / LTA4 and Muscle
 Bone Marrow Antibodies  >4 publications with LTA4H / LTA4 and Bone Marrow
 Intestine Antibodies  >3 publications with LTA4H / LTA4 and Intestine
 Skin Antibodies  >2 publications with LTA4H / LTA4 and Skin
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