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TET3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249272

TET3 Antibody, HCG_40738 Antibody, KIAA0401 Antibody Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TET3, Monoclonal Antibody
Full Product Name
Anti-TET3 Antibody (aa241-568, clone 11E11) IHC-plus
Product Gene Name
anti-TET3 antibody
Product Synonym Names
Mouse Monoclonal [clone 11E11] (IgG1) to Human TET3; Human TET3; HCG_40738; KIAA0401
Clonality
Monoclonal
Isotype
IgG1
Clone Number
11E11
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
Human TET3
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
77,471 Da
OMIM
613555
3D Structure
ModBase 3D Structure for O43151
Immunogen
TET3 antibody was raised against human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E Coli.
Immunogen Description
Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E Coli.
Immunogen Type
Recombinant protein
Antigen Modification
aa241-568
Target Species
Human
Applications Tested/Suitable for anti-TET3 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-TET3 antibody
IHC-P (1:15, 10 ug/ml)
WB (1:2000)

Immunohistochemistry - Paraffin (IHC) of anti-TET3 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-TET3 Monoclonal Antibody – Cat# MBS249272

Western Blot (WB) of anti-TET3 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TET3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TET3.
Mouse Anti-TET3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249272

Other Notes

Small volumes of anti-TET3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TET3 purchase

MBS249272 is an antibody targeting TET3. Also known as Anti-TET3 Antibody (aa241-568, clone 11E11) IHC-plus. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TET3. It may not necessarily be applicable to this product.

NCBI GI #
149944516
NCBI GeneID
200424
NCBI Accession #
NP_659430.1
UniProt Primary Accession #
O43151
UniProt Secondary Accession #
Q86Z24; Q8TBM9; A6NEI3
UniProt Related Accession #
O43151
GenBank Nucleotide #
NM_144993.1
NCBI Official Synonym Full Names
tet methylcytosine dioxygenase 3
NCBI Official Symbol
TET3
NCBI Official Synonym Symbols
hCG_40738
UniProt Protein Name
Methylcytosine dioxygenase TET3
Protein Family
Methylcytosine dioxygenase
UniProt Gene Name
TET3
UniProt Synonym Gene Names
KIAA0401
UniProt Entry Name
TET3_HUMAN
NCBI Protein Information
methylcytosine dioxygenase TET3

NCBI Summary for TET3

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

UniProt Comments for TET3

TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.n2; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytoplasm; female pronucleus; male pronucleus

Molecular Function: DNA binding; metal ion binding; protein binding

Biological Process: gene expression; positive regulation of transcription from RNA polymerase II promoter; protein amino acid O-linked glycosylation; regulation of gene expression, epigenetic
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Research Articles on TET3

1. Hypoxia deregulates TET3. TET1/3 levels were associated with tumor hypoxia, tumor malignancy, and poor prognosis in breast cancer patients. Coordinate functions of TET1 and TET3 were needed to activate TNFalpha-p38-MAPK signaling in hypoxia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TET3 antibody

 Reference Product  PubMed Publications
 TDG antibody  >17 publications with TET3 and TDG
 DNMT1 antibody  >14 publications with TET3 and DNMT1
 DNMT3A antibody  >12 publications with TET3 and DNMT3A
 OGT antibody  >9 publications with TET3 and OGT
 NANOG antibody  >5 publications with TET3 and NANOG
 ASXL1 antibody  >2 publications with TET3 and ASXL1
 HCFC1 antibody  >1 publications with TET3 and HCFC1
 SIN3A antibody  >1 publications with TET3 and SIN3A

Pathways associated with anti-TET3 antibody

 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram

Organs/Tissues associated with anti-TET3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with TET3 and Brain
 Embryonic Tissue Antibodies  >8 publications with TET3 and Embryonic Tissue
 Liver Antibodies  >8 publications with TET3 and Liver
 Blood Antibodies  >7 publications with TET3 and Blood
 Bone Antibodies  >6 publications with TET3 and Bone
 Eye Antibodies  >3 publications with TET3 and Eye
 Skin Antibodies  >2 publications with TET3 and Skin
 Prostate Antibodies  >2 publications with TET3 and Prostate
 Ovary Antibodies  >2 publications with TET3 and Ovary
 Lung Antibodies  >2 publications with TET3 and Lung
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