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CHTOP Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249298

CHTOP Antibody, C1orf77 Antibody, Chromatin target of PRMT1 Antibody, DKFZP547E1010 Antibody, FOP Antibody, Friend of PRMT1 protein Antibody, Pp7704 Antibody, SRAG Antibody, SRAG-3 Antibody, SRAG-5 Antibody, FL-SRAG Antibody, RP1-178F15.2 Antibody… More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHTOP / FOP, Monoclonal Antibody
Full Product Name
Anti-CHTOP / FOP Antibody (C-Terminus, clone KT64) IHC-plus
Product Gene Name
Product Synonym Gene Name
FOP
Product Synonym Names
Rat Monoclonal [clone KT64] (IgG2a) to Mouse CHTOP / FOP; Mouse CHTOP / FOP; CHTOP; C1orf77; Chromatin target of PRMT1; DKFZP547E1010; FOP; Friend of PRMT1 protein; Pp7704; SRAG; SRAG-3; SRAG-5; FL-SRAG; RP1-178F15.2
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
KT64
Host
Rat
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.1% sodium azide
Purity/Purification
Protein A purified
Concentration
1 mg/ml (lot specific)
Specificity
Mouse CHTOP / FOP
Preparation and Storage
Short term 4 degree C
Long term aliquot and store at -20 degree C
Avoid freeze thaw cycles.
Molecular Weight
21,918 Da
OMIM
614206
3D Structure
ModBase 3D Structure for Q9Y3Y2
Immunogen
CHTOP / FOP antibody was raised against mouse Friend of Prmt1 C-terminus and GST fusion protein.
Immunogen Description
Mouse Friend of Prmt1 C-terminus and GST fusion protein.
Immunogen Type
Fusion protein
Antigen Modification
C-Terminus
Target Species
Mouse
Applications Tested/Suitable for anti-CHTOP antibody
Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-CHTOP antibody
ICC (1:100)
IHC-P (10 ug/ml)
WB (1:1000)

Immunohistochemistry (IHC) of anti-CHTOP antibody

Anti-CHTOP / FOP antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rat Anti-CHTOP Monoclonal Antibody – Cat# MBS249298

Other Notes

Small volumes of anti-CHTOP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHTOP purchase

MBS249298 is an antibody targeting CHTOP. Also known as Anti-CHTOP / FOP Antibody (C-Terminus, clone KT64) IHC-plus. Reactive in Mouse, Human. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CHTOP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
chromatin target of PRMT1 protein isoform 1
NCBI Official Synonym Full Names
chromatin target of PRMT1
NCBI Official Symbol
CHTOP
NCBI Official Synonym Symbols
FOP; SRAG; SRAG-3; SRAG-5; pp7704; C1orf77; FL-SRAG
UniProt Protein Name
Chromatin target of PRMT1 protein
UniProt Synonym Protein Names
Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG
UniProt Gene Name
CHTOP
UniProt Synonym Gene Names
C1orf77; FOP; SRAG
UniProt Entry Name
CHTOP_HUMAN
NCBI Protein Information
chromatin target of PRMT1 protein

NCBI Summary for CHTOP

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]
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UniProt Comments for CHTOP

CHTOP: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: intracellular membrane-bound organelle; nuclear speck; nucleolus; nucleoplasm

Molecular Function: methyl-CpG binding; protein binding

Biological Process: mRNA export from nucleus; positive regulation of ATPase activity; positive regulation of cell proliferation; positive regulation of helicase activity; positive regulation of histone methylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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