SKIL / SNO / SnoN Antibody – Mouse Monoclonal

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SKIL: May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: acrosome; cytoplasm; nucleoplasm; nucleus; PML body; protein complex

Molecular Function: chromatin binding; DNA binding; protein binding; protein complex binding; protein domain specific binding; SMAD binding; transcription corepressor activity

Biological Process: blastocyst formation; cell cycle arrest; gene expression; lymphocyte homeostasis; negative regulation of cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of axonogenesis; regulation of apoptosis; response to antibiotic; response to cytokine stimulus; skeletal muscle development; spermatogenesis; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway