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COMMD1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249348

COMMD1 Antibody, C2orf5 Antibody, Protein Murr1 Antibody, Copper metabolism gene MURR1 Antibody, MURR1 Antibody Description: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity.… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
COMMD1, Monoclonal Antibody
Full Product Name
Anti-COMMD1 Antibody (clone 2E2) IHC-plus
Product Gene Name
anti-COMMD1 antibody
Product Synonym Names
Mouse Monoclonal [clone 2E2] (IgG2a) to Human COMMD1; Human COMMD1; C2orf5; Protein Murr1; Copper metabolism gene MURR1; MURR1
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2E2
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Protein A/G purified
Concentration
1 mg/ml (lot specific)
Specificity
Human COMMD1
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
17,665 Da
OMIM
607238
3D Structure
ModBase 3D Structure for Q8N668
Immunogen
COMMD1 antibody was raised against full length human recombinant protein of human COMMD1(NP_689729) produced in HEK293T cell.
Immunogen Description
Full length human recombinant protein of human COMMD1(NP_689729) produced in HEK293T cell.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-COMMD1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-COMMD1 antibody
Flow Cytometry (1:100)
IHC-P (10 ug/ml)
WB (1:2000)

Immunohistochemistry (IHC) of anti-COMMD1 antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-COMMD1 Monoclonal Antibody – Cat# MBS249348

Immunohistochemistry (IHC) of anti-COMMD1 antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-COMMD1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS249348

Western Blot (WB) of anti-COMMD1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COMMD1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COMMD1.
Mouse Anti-COMMD1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249348

Western Blot (WB) of anti-COMMD1 antibody

Western blot of extracts (35 ug) from 9 different cell lines by using g anti-COMMD1 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
Mouse Anti-COMMD1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249348

Flow Cytometry (FC/FACS) of anti-COMMD1 antibody

Flow cytometry of HeLa cells, using anti-COMMD1 antibody (Red), compared to a nonspecific negative control antibody (Blue).
Mouse Anti-COMMD1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249348

Flow Cytometry (FC/FACS) of anti-COMMD1 antibody

HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-COMMD1 antibody, and then analyzed by flow cytometry.
Mouse Anti-COMMD1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249348

Flow Cytometry (FC/FACS) of anti-COMMD1 antibody

Flow cytometry of Jurkat cells, using anti-COMMD1 antibody (Red), compared to a nonspecific negative control antibody (Blue).
Mouse Anti-COMMD1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249348

Other Notes

Small volumes of anti-COMMD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COMMD1 purchase

MBS249348 is an antibody targeting COMMD1. Also known as Anti-COMMD1 Antibody (clone 2E2) IHC-plus. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for COMMD1. It may not necessarily be applicable to this product.

NCBI GI #
51316026
NCBI GeneID
150684
NCBI Accession #
Q8N668.1
UniProt Primary Accession #
Q8N668
UniProt Secondary Accession #
Q96GS0; B4DFQ4
UniProt Related Accession #
Q8N668
NCBI Official Full Name
COMM domain-containing protein 1
NCBI Official Synonym Full Names
copper metabolism domain containing 1
NCBI Official Symbol
COMMD1
NCBI Official Synonym Symbols
MURR1; C2orf5
UniProt Protein Name
COMM domain-containing protein 1
UniProt Synonym Protein Names
Protein Murr1
Protein Family
COMM domain-containing protein
UniProt Gene Name
COMMD1
UniProt Synonym Gene Names
C2orf5; MURR1
UniProt Entry Name
COMD1_HUMAN
NCBI Protein Information
COMM domain-containing protein 1

NCBI Summary for COMMD1

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

UniProt Comments for COMMD1

COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleoplasm; nucleus; recycling endosome

Molecular Function: copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity

Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; protein transport; regulation of proteasomal ubiquitin-dependent protein catabolic process; transcription, DNA-dependent
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Research Articles on COMMD1

1. COMMD1 expression is associated with poor prognosis in diffuse large B-cell lymphoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COMMD1 antibody

 Reference Product  PubMed Publications
 ATP7B antibody  >26 publications with COMMD1 and ATP7B
 RELA antibody  >16 publications with COMMD1 and RELA
 XIAP antibody  >8 publications with COMMD1 and XIAP
 CUL2 antibody  >5 publications with COMMD1 and CUL2
 COMMD6 antibody  >2 publications with COMMD1 and COMMD6
 NMRAL1 antibody  >1 publications with COMMD1 and NMRAL1

Pathways associated with anti-COMMD1 antibody

 Products by Pathway  Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-COMMD1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >28 publications with COMMD1 and Liver Diseases
 Nervous System Diseases Antibodies  >21 publications with COMMD1 and Nervous System Diseases
 Inflammation Antibodies  >13 publications with COMMD1 and Inflammation
 Dog Diseases Antibodies  >12 publications with COMMD1 and Dog Diseases
 Liver Cirrhosis Antibodies  >8 publications with COMMD1 and Liver Cirrhosis
 Necrosis Antibodies  >7 publications with COMMD1 and Necrosis
 Fibrosis Antibodies  >7 publications with COMMD1 and Fibrosis
 Disease Models, Animal Antibodies  >7 publications with COMMD1 and Disease Models, Animal
 Immune System Diseases Antibodies  >5 publications with COMMD1 and Immune System Diseases
 Hepatitis, Chronic Antibodies  >3 publications with COMMD1 and Hepatitis, Chronic

Organs/Tissues associated with anti-COMMD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >33 publications with COMMD1 and Liver
 Blood Antibodies  >15 publications with COMMD1 and Blood
 Brain Antibodies  >12 publications with COMMD1 and Brain
 Embryonic Tissue Antibodies  >4 publications with COMMD1 and Embryonic Tissue
 Placenta Antibodies  >4 publications with COMMD1 and Placenta
 Kidney Antibodies  >4 publications with COMMD1 and Kidney
 Intestine Antibodies  >4 publications with COMMD1 and Intestine
 Lung Antibodies  >4 publications with COMMD1 and Lung
 Muscle Antibodies  >2 publications with COMMD1 and Muscle
 Prostate Antibodies  >1 publications with COMMD1 and Prostate
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