CGRP Antibody – Mouse Monoclonal

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: cell soma; cytoplasm; cytosol; extracellular region; extracellular space; nucleus; terminal button

Molecular Function: calcitonin receptor binding; hormone activity; identical protein binding; protein binding; protein complex binding; receptor binding

Biological Process: activation of protein kinase activity; adenylate cyclase activation; aging; antibacterial humoral response; antifungal humoral response; cell-cell signaling; cellular protein metabolic process; cytosolic calcium ion homeostasis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of temperature stimulus involved in sensory perception of pain; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; endothelial cell migration; endothelial cell proliferation; feeding behavior; G-protein coupled receptor internalization; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; innate immune response; leukocyte adhesion; monocyte chemotaxis; negative regulation of blood pressure; negative regulation of bone resorption; negative regulation of neurological process; negative regulation of ossification; negative regulation of osteoclast differentiation; negative regulation of smooth muscle contraction; negative regulation of transcription, DNA-dependent; neuropeptide signaling pathway; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of ossification; positive regulation of vasodilation; protein amino acid phosphorylation; receptor internalization; regulation of blood pressure; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; response to yeast; vasculature development; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure