SYN / FYN Antibody – Mouse Monoclonal

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

Fyn: a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy.

Protein type: Kinase, protein; Protein kinase, TK; Oncoprotein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Src family

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: actin filament; cytosol; endosome; extrinsic to internal side of plasma membrane; lipid raft; mitochondrion; nucleus; plasma membrane; postsynaptic density

Molecular Function: ATP binding; CD4 receptor binding; CD8 receptor binding; ephrin receptor binding; G-protein-coupled receptor binding; glycoprotein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; peptide hormone receptor binding; phosphoinositide 3-kinase binding; protein binding; protein-tyrosine kinase activity; T cell receptor binding; tubulin binding

Biological Process: activated T cell proliferation; activation of MAPKK activity; adaptive immune response; axon guidance; blood coagulation; calcium ion transport; cell differentiation; cell migration; dendrite morphogenesis; detection of mechanical stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; feeding behavior; fibroblast growth factor receptor signaling pathway; forebrain development; innate immune response; insulin receptor signaling pathway; learning; leukocyte migration; MAPKKK cascade; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; nerve growth factor receptor signaling pathway; neuron migration; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of Stat5 protein; protein amino acid phosphorylation; Ras protein signal transduction; regulation of apoptosis; regulation of cell proliferation; regulation of cell shape; regulation of defense response to virus by virus; response to drug; response to ethanol; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction