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ALOX15 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249435

ALOX15 Antibody, 15-lipoxygenase Antibody, 15-LOX Antibody, 15-lipooxygenase-1 Antibody, 15-LO-1 Antibody, 15LOX-1 Antibody, 15-LOX-1 Antibody, LOG15 Antibody, Arachidonate 15-lipoxygenase Antibody Description: Non-heme iron-containing dioxygenase that… More details

$650 / 0.05 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ALOX15 / 15-Lipoxygenase, Monoclonal Antibody
Full Product Name
Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 7H6) IHC-plus
Product Gene Name
anti-ALOX15 antibody
Product Synonym Names
Mouse Monoclonal [clone 7H6] (IgG2b) to Human ALOX15 / 15-Lipoxygenase; Human ALOX15 / 15-Lipoxygenase; 15-lipoxygenase; 15-LOX; 15-lipooxygenase-1; 15-LO-1; 15LOX-1; 15-LOX-1; LOG15; Arachidonate 15-lipoxygenase
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
7H6
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Protein A/G purified
Concentration
1.21 mg/ml (lot specific)
Specificity
Human 15-LOX / ALOX15
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
70,108 Da
OMIM
152392
3D Structure
ModBase 3D Structure for P16050
Immunogen
ALOX15 / 15-Lipoxygenase antibody was raised against full length human recombinant protein of human ALOX15(NP_001131) produced in HEK293T cell.
Immunogen Description
Full length human recombinant protein of human ALOX15(NP_001131) produced in HEK293T cell.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-ALOX15 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-ALOX15 antibody
Flow Cytometry (1:100)
IF (1:100)
IHC-P (10 ug/ml)
WB (1:2000)

Immunohistochemistry - Paraffin (IHC) of anti-ALOX15 antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-ALOX15 Monoclonal Antibody – Cat# MBS249435

Immunohistochemistry - Paraffin (IHC) of anti-ALOX15 antibody

Human Lung, Respiratory Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-ALOX15 Monoclonal Antibody, Immunohistochemistry - Paraffin (IHC) – Cat# MBS249435

Immunofluorescence (IF) of anti-ALOX15 antibody

Anti-ALOX15 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ALOX15.
Mouse Anti-ALOX15 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS249435

Western Blot (WB) of anti-ALOX15 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALOX15 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ALOX15.
Mouse Anti-ALOX15 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249435

Flow Cytometry (FC/FACS) of anti-ALOX15 antibody

HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-ALOX15 antibody, and then analyzed by flow cytometry.
Mouse Anti-ALOX15 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249435

Other Notes

Small volumes of anti-ALOX15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALOX15 purchase

MBS249435 is an antibody targeting ALOX15. Also known as Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 7H6) IHC-plus. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOX15. It may not necessarily be applicable to this product.

NCBI GI #
40316937
NCBI GeneID
246
NCBI Accession #
NP_001131.3
UniProt Primary Accession #
P16050
UniProt Secondary Accession #
Q8N6R7; Q99657; A8K2P4; B7ZA11
UniProt Related Accession #
P16050
GenBank Nucleotide #
NM_001140.3
NCBI Official Full Name
arachidonate 15-lipoxygenase
NCBI Official Synonym Full Names
arachidonate 15-lipoxygenase
NCBI Official Symbol
ALOX15
NCBI Official Synonym Symbols
12-LOX; 15LOX-1; 15-LOX-1
UniProt Protein Name
Arachidonate 15-lipoxygenase
UniProt Synonym Protein Names
12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type (EC:1.13.11.31
UniProt Gene Name
ALOX15
UniProt Synonym Gene Names
LOG15; 12-LOX
UniProt Entry Name
LOX15_HUMAN
NCBI Protein Information
arachidonate 15-lipoxygenase

UniProt Comments for ALOX15

ALOX15: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid. Belongs to the lipoxygenase family.

Protein type: EC 1.13.11.31; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.13.11.33; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytosol; extrinsic to internal side of plasma membrane; lipid particle; membrane; plasma membrane

Molecular Function: arachidonate 12-lipoxygenase activity; arachidonate 15-lipoxygenase activity; hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; iron ion binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: apoptotic cell clearance; arachidonic acid metabolic process; bone mineralization; hepoxilin biosynthetic process; inflammatory response; leukotriene metabolic process; lipoxygenase pathway; negative regulation of adaptive immune response; ossification; phosphatidylethanolamine biosynthetic process; positive regulation of actin filament polymerization; positive regulation of heterotypic cell-cell adhesion; wound healing
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Research Articles on ALOX15

1. limiting ALOX15 expression by AMPK may promote an anti-inflammatory phenotype of IL-4-stimulated human macrophages

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALOX15 antibody

 Reference Product  PubMed Publications
 PTGS2 antibody  >60 publications with ALOX15 and PTGS2
 PTGS1 antibody  >29 publications with ALOX15 and PTGS1
 PLA2G4A antibody  >19 publications with ALOX15 and PLA2G4A
 STAT6 antibody  >14 publications with ALOX15 and STAT6
 ALOX5AP antibody  >9 publications with ALOX15 and ALOX5AP
 GPX3 antibody  >1 publications with ALOX15 and GPX3
 PLA2G5 antibody  >1 publications with ALOX15 and PLA2G5
 LTC4S antibody  >1 publications with ALOX15 and LTC4S

Pathways associated with anti-ALOX15 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-ALOX15 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >238 publications with ALOX15 and Inflammation
 Cardiovascular Diseases Antibodies  >142 publications with ALOX15 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >140 publications with ALOX15 and Atherosclerosis
 Disease Models, Animal Antibodies  >81 publications with ALOX15 and Disease Models, Animal
 Lung Diseases Antibodies  >72 publications with ALOX15 and Lung Diseases
 Hypertension Antibodies  >42 publications with ALOX15 and Hypertension
 Necrosis Antibodies  >30 publications with ALOX15 and Necrosis
 Kidney Diseases Antibodies  >24 publications with ALOX15 and Kidney Diseases
 Heart Diseases Antibodies  >23 publications with ALOX15 and Heart Diseases
 Fibrosis Antibodies  >19 publications with ALOX15 and Fibrosis

Organs/Tissues associated with anti-ALOX15 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >113 publications with ALOX15 and Lung
 Prostate Antibodies  >48 publications with ALOX15 and Prostate
 Trachea Antibodies  >17 publications with ALOX15 and Trachea
 Intestine Antibodies  >16 publications with ALOX15 and Intestine
 Adipose Tissue Antibodies  >14 publications with ALOX15 and Adipose Tissue
 Embryonic Tissue Antibodies  >13 publications with ALOX15 and Embryonic Tissue
 Placenta Antibodies  >13 publications with ALOX15 and Placenta
 Lymph Node Antibodies  >7 publications with ALOX15 and Lymph Node
 Testis Antibodies  >3 publications with ALOX15 and Testis
 Mouth Antibodies  >3 publications with ALOX15 and Mouth
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