FGF19 Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family.

Protein type: Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis; Cell development/differentiation; Secreted

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: extracellular region; intracellular

Molecular Function: fibroblast growth factor receptor binding; growth factor activity; protein binding

Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; nervous system development; neural crest cell migration; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of glucose import; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway