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ITGB2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9231826

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple… More details

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Product Overview

Online Datasheet in PDF
Product Name
ITGB2, Monoclonal Antibody
Full Product Name
ITGB2 Antibody
Product Gene Name
anti-ITGB2 antibody
Product Synonym Names
ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen=CD18; Flags: Precursor
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Species Reactivity
Human
Form/Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purity/Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Specificity
Purified His-tagged ITGB2 protein(Fragment) was used to produced this monoclonal antibody.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks . For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
Calculated MW: H = 85 KDa
OMIM
116920
3D Structure
ModBase 3D Structure for P05107
Antigen Source
Human
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3- mediated activation of TNF primed neutrophils (PubMed:21193407).
Cellular Location
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein
Tissue Location
Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980)

Product Categories/Family for anti-ITGB2 antibody

Stem Cells
Applications Tested/Suitable for anti-ITGB2 antibody
Western Blot (WB), Immunohistochemistry (IHC-P) Paraffin, ELISA (EIA)
Application Notes for anti-ITGB2 antibody
WB: 1:1000
IHC-P: 1:25

Western Blot (WB) of anti-ITGB2 antibody

Western blot analysis of lysates from HL-60,K562 cell line (from left to right), using ITGB2 Antibody MBS9231826. It was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
Mouse Anti-ITGB2 Monoclonal Antibody – Cat# MBS9231826

Immunohistochemistry (IHC)-Paraffin of anti-ITGB2 antibody

Immunohistochemical analysis of paraffin-embedded H. tonsil section using ITGB2 Antibody MBS9231826. It was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
Mouse Anti-ITGB2 Monoclonal Antibody, Immunohistochemistry (IHC)-Paraffin – Cat# MBS9231826

Product References and Citations for anti-ITGB2 antibody

Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010). Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010). Pliyev, B.K., et al. Biochem. Biophys. Res. Commun. 397(2):277-282(2010).

Other Notes

Small volumes of anti-ITGB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGB2 purchase

MBS9231826 is an antibody targeting ITGB2. Also known as ITGB2 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGB2. It may not necessarily be applicable to this product.

NCBI GI #
89191865
NCBI GeneID
3689
NCBI Accession #
NP_000202.2
NCBI Related Accession #
NP_001120963.1
UniProt Primary Accession #
P05107
GenBank Nucleotide #
NP_000202.2
NCBI Official Full Name
integrin beta-2
UniProt Protein Name
Integrin beta-2
UniProt Synonym Protein Names
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta
Protein Family
Integrin
UniProt Gene Name
ITGB2
UniProt Synonym Gene Names
CD18; MFI7
UniProt Entry Name
ITB2_HUMAN

UniProt Comments for ITGB2

ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).

Protein type: Receptor, misc.; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Cell surface

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex; vesicle; lipid raft

Molecular Function: protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cellular extravasation; cell-cell signaling; inflammatory response; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; endothelial cell migration; innate immune response; blood coagulation; leukocyte migration

Disease: Leukocyte Adhesion Deficiency, Type I
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGB2 antibody

 Reference Product  PubMed Publications
 ITGAM antibody  >1599 publications with ITGB2 and ITGAM
 ICAM1 antibody  >858 publications with ITGB2 and ICAM1
 ITGAX antibody  >395 publications with ITGB2 and ITGAX
 CD14 antibody  >304 publications with ITGB2 and CD14
 ICAM2 antibody  >58 publications with ITGB2 and ICAM2
 ICAM3 antibody  >48 publications with ITGB2 and ICAM3
 SYK antibody  >38 publications with ITGB2 and SYK
 PRTN3 antibody  >12 publications with ITGB2 and PRTN3
 ITGAD antibody  >12 publications with ITGB2 and ITGAD
 PTK2 antibody  >9 publications with ITGB2 and PTK2

Pathways associated with anti-ITGB2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-ITGB2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >870 publications with ITGB2 and Inflammation
 Necrosis Antibodies  >602 publications with ITGB2 and Necrosis
 Neoplasms Antibodies  >403 publications with ITGB2 and Neoplasms
 Cardiovascular Diseases Antibodies  >392 publications with ITGB2 and Cardiovascular Diseases
 Lung Diseases Antibodies  >207 publications with ITGB2 and Lung Diseases
 Leukocyte-Adhesion Deficiency Syndrome Antibodies  >160 publications with ITGB2 and Leukocyte-Adhesion Deficiency Syndrome
 Heart Diseases Antibodies  >127 publications with ITGB2 and Heart Diseases
 Leukocyte Disorders Antibodies  >113 publications with ITGB2 and Leukocyte Disorders
 Hypersensitivity Antibodies  >107 publications with ITGB2 and Hypersensitivity
 Drug Toxicity Antibodies  >91 publications with ITGB2 and Drug Toxicity

Organs/Tissues associated with anti-ITGB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3633 publications with ITGB2 and Blood
 Lung Antibodies  >359 publications with ITGB2 and Lung
 Bone Antibodies  >283 publications with ITGB2 and Bone
 Bone Marrow Antibodies  >254 publications with ITGB2 and Bone Marrow
 Heart Antibodies  >178 publications with ITGB2 and Heart
 Muscle Antibodies  >153 publications with ITGB2 and Muscle
 Liver Antibodies  >124 publications with ITGB2 and Liver
 Embryonic Tissue Antibodies  >121 publications with ITGB2 and Embryonic Tissue
 Kidney Antibodies  >101 publications with ITGB2 and Kidney
 Spleen Antibodies  >100 publications with ITGB2 and Spleen
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