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BMP2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249463

BMP2 Antibody, BDA2 Antibody, BMP-2 Antibody, BMP-2A Antibody, BMP2A Antibody, Bone morphogenetic protein 2 Antibody, Bone morphogenetic protein 2A Antibody Description: BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
BMP2, Monoclonal Antibody
Full Product Name
Anti-BMP2 Antibody (clone AT15B3) IHC-plus
Product Gene Name
Product Synonym Names
Mouse Monoclonal [clone AT15B3] (IgG2b,k) to Human BMP2; Human BMP2; BDA2; BMP-2; BMP-2A; BMP2A; Bone morphogenetic protein 2; Bone morphogenetic protein 2A
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
AT15B3
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied in PBS, pH 7.4, 10% glycerol, 0.02% sodium azide
Purity/Purification
Protein A purified
Concentration
1 mg/ml (lot specific)
Specificity
Human BMP2 / BMP-2
Preparation and Storage
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
44,702 Da
OMIM
112261
3D Structure
ModBase 3D Structure for P12643
Immunogen
BMP2 antibody was raised against recombinant human BMP2 (283-396aa) purified from E Coli.
Immunogen Description
Recombinant human BMP2 (283-396aa) purified from E Coli.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-BMP2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-BMP2 antibody
IHC-P (10 ug/ml)
WB (1:500 - 1:2000)

Immunohistochemistry (IHC) of anti-BMP2 antibody

Anti-BMP2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-BMP2 Monoclonal Antibody – Cat# MBS249463

Western Blot (WB) of anti-BMP2 antibody

Western Blot: The lysate of HeLa (30 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP2 antibody(1:500-1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Mouse Anti-BMP2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249463

Other Notes

Small volumes of anti-BMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP2 purchase

MBS249463 is an antibody targeting BMP2. Also known as Anti-BMP2 Antibody (clone AT15B3) IHC-plus. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bone morphogenetic protein 2 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
BMP2
NCBI Official Synonym Symbols
BDA2; BMP2A
UniProt Protein Name
Bone morphogenetic protein 2
UniProt Synonym Protein Names
Bone morphogenetic protein 2A; BMP-2A
UniProt Gene Name
BMP2
UniProt Synonym Gene Names
BMP2A; BMP-2; BMP-2A
UniProt Entry Name
BMP2_HUMAN
NCBI Protein Information
bone morphogenetic protein 2

NCBI Summary for BMP2

This gene encodes a member of the transforming growth factor-beta (TGFB) superfamily. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which induces bone and cartilage formation. [provided by RefSeq, Nov 2015]

UniProt Comments for BMP2

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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