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RTN1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249467

RTN1 Antibody, Reticulon-1 Antibody, NSP Antibody, Reticulon 1 Antibody Description: RTN1 / Reticulon 1 belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion… More details

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Product Overview

Product Name
RTN1 / Reticulon 1, Monoclonal Antibody
Full Product Name
Anti-RTN1 / Reticulon 1 Antibody (clone RNL-2) IHC-plus
Product Gene Name
Product Synonym Names
Mouse Monoclonal [clone RNL-2] (IgG1) to Human RTN1 / Reticulon 1; Human RTN1 / Reticulon 1; Reticulon-1; NSP; Reticulon 1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
RNL-2
Host
Mouse
Species Reactivity
Rabbit, Human, Monkey
Form/Format
PBS containing 0.09% sodium azide
Purity/Purification
Purified
Concentration
1 mg/ml (lot specific)
Specificity
Recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A), which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, antibody reacts with brain Purkinje cells, pancreatic islet cells, cells in the pituitary gland and some (peripheral) nerve fibers. In addition, a few epithelia show positive staining.
Preparation and Storage
Short term 4 degree C
Long term aliquot and store at -20 degree C
Avoid freeze thaw cycles. Store undiluted.
Molecular Weight
23,576 Da
OMIM
600865
3D Structure
ModBase 3D Structure for Q16799
Immunogen
RTN1 / Reticulon 1 antibody was raised against small cell lung cancer cell line NCI-H82
Immunogen Description
Small cell lung cancer cell line NCI-H82
Target Species
Human
Applications Tested/Suitable for anti-RTN1 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-RTN1 antibody
Flow Cytometry (1:25 - 1:200)
IHC-Fr (1:25 - 1:200)
IHC-P (10 ug/ml)
WB (1:100 - 1:1000)

Immunohistochemistry (IHC) of anti-RTN1 antibody

Anti-Reticulon 1/2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-RTN1 Monoclonal Antibody – Cat# MBS249467

Other Notes

Small volumes of anti-RTN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RTN1 purchase

MBS249467 is an antibody targeting RTN1. Also known as Anti-RTN1 / Reticulon 1 Antibody (clone RNL-2) IHC-plus. Reactive in Rabbit, Human, Monkey. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for RTN1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
reticulon-1 isoform A
NCBI Official Synonym Full Names
reticulon 1
NCBI Official Symbol
RTN1
NCBI Official Synonym Symbols
NSP
UniProt Protein Name
Reticulon-1
UniProt Synonym Protein Names
Neuroendocrine-specific protein
Protein Family
UniProt Gene Name
RTN1
UniProt Synonym Gene Names
NSP
UniProt Entry Name
RTN1_HUMAN
NCBI Protein Information
reticulon-1

NCBI Summary for RTN1

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
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UniProt Comments for RTN1

RTN1: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q23.1

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: neuron differentiation
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Research Articles on RTN1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RTN1 antibody

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