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CLASP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249498

CLASP1 Antibody, CLIP-associating protein 1 Antibody, HOrbit1 Antibody, Multiple asters homolog 1 Antibody, KIAA0622 Antibody, Multiple asters 1 Antibody, Protein Orbit homolog 1 Antibody Description: Microtubule plus-end tracking protein that promotes the… More details

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Product Overview

Product Name
CLASP1, Polyclonal Antibody
Full Product Name
Anti-CLASP1 Antibody (aa1171-1220) IHC-plus
Product Gene Name
anti-CLASP1 antibody
Product Synonym Names
Rabbit Polyclonal (IgG) to Human CLASP1; Human CLASP1; CLIP-associating protein 1; HOrbit1; Multiple asters homolog 1; KIAA0622; Multiple asters 1; Protein Orbit homolog 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity purified
Specificity
CLASP1 Antibody detects endogenous levels of total CLASP1 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
162,914 Da
OMIM
605852
3D Structure
ModBase 3D Structure for Q7Z460
Immunogen
CLASP1 antibody was raised against synthetic peptide from human CLASP1 (aa1171-1220).
Immunogen Description
Synthetic peptide from human CLASP1 (aa1171-1220).
Antigen Modification
aa1171-1220
Target Species
Human
Applications Tested/Suitable for anti-CLASP1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLASP1 antibody
ELISA (1:40000)
IHC-P (10 ug/ml)
WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-CLASP1 antibody

Anti-CLASP1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-CLASP1 Polyclonal Antibody – Cat# MBS249498

Western Blot (WB) of anti-CLASP1 antibody

Western blot of extracts from Jurkat cells, using CLASP1 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-CLASP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249498

Other Notes

Small volumes of anti-CLASP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLASP1 purchase

MBS249498 is an antibody targeting CLASP1. Also known as Anti-CLASP1 Antibody (aa1171-1220) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLASP1. It may not necessarily be applicable to this product.

NCBI GI #
31563537
NCBI GeneID
23332
NCBI Accession #
NP_056097.1
UniProt Primary Accession #
Q7Z460
UniProt Secondary Accession #
O75118; Q2KHQ9; Q5H9P0; Q8N5B8; Q9BQT5; A2RU21; B7ZLX3; F5GWS0
UniProt Related Accession #
Q7Z460
GenBank Nucleotide #
NM_015282.2
NCBI Official Full Name
CLIP-associating protein 1 isoform 1
NCBI Official Synonym Full Names
cytoplasmic linker associated protein 1
NCBI Official Symbol
CLASP1
NCBI Official Synonym Symbols
MAST1
UniProt Protein Name
CLIP-associating protein 1
UniProt Synonym Protein Names
Cytoplasmic linker-associated protein 1; Multiple asters homolog 1; Protein Orbit homolog 1; hOrbit1
Protein Family
CLIP-associating protein
UniProt Gene Name
CLASP1
UniProt Synonym Gene Names
KIAA0622; MAST1; hOrbit1
UniProt Entry Name
CLAP1_HUMAN
NCBI Protein Information
CLIP-associating protein 1

NCBI Summary for CLASP1

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

UniProt Comments for CLASP1

CLASP1: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Belongs to the CLASP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q14.2-q14.3

Cellular Component: basal cortex; cell cortex; centrosome; cortical microtubule cytoskeleton; cytoplasmic microtubule; cytosol; focal adhesion; Golgi apparatus; kinetochore; kinetochore microtubule; membrane; spindle microtubule

Molecular Function: kinetochore binding; microtubule binding; microtubule plus-end binding; protein binding

Biological Process: astral microtubule organization and biogenesis; axon guidance; cell division; establishment and/or maintenance of cell polarity; establishment of mitotic spindle localization; establishment of spindle orientation; exit from mitosis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; microtubule bundle formation; microtubule cytoskeleton organization and biogenesis; microtubule nucleation; microtubule organizing center organization and biogenesis; mitotic cell cycle; mitotic spindle organization and biogenesis; negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization or depolymerization; negative regulation of stress fiber formation; organelle organization and biogenesis; positive regulation of exocytosis; positive regulation of microtubule polymerization; regulation of focal adhesion formation; regulation of gastrulation; small GTPase mediated signal transduction; vesicle targeting
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Research Articles on CLASP1

1. Acute silencing of CLASP1, a +TIP that participates in microtubule stabilization at the cell periphery, impairs trypomastigote internalization without diminishing the capacity for calcium-regulated lysosome exocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLASP1 antibody

 Reference Product  PubMed Publications
 MAPRE1 antibody  >2 publications with CLASP1 and MAPRE1
 CLIP1 antibody  >1 publications with CLASP1 and CLIP1
 KIF2B antibody  >1 publications with CLASP1 and KIF2B

Pathways associated with anti-CLASP1 antibody

 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram

Diseases associated with anti-CLASP1 antibody

 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >1 publications with CLASP1 and Craniofacial Abnormalities
 Nervous System Diseases Antibodies  >1 publications with CLASP1 and Nervous System Diseases
 Fetal Growth Retardation Antibodies  >1 publications with CLASP1 and Fetal Growth Retardation
 Fetal Death Antibodies  >1 publications with CLASP1 and Fetal Death

Organs/Tissues associated with anti-CLASP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with CLASP1 and Brain
 Blood Antibodies  >2 publications with CLASP1 and Blood
 Heart Antibodies  >1 publications with CLASP1 and Heart
 Bone Antibodies  >1 publications with CLASP1 and Bone
 Muscle Antibodies  >1 publications with CLASP1 and Muscle
 Eye Antibodies  >1 publications with CLASP1 and Eye
 Mammary Gland Antibodies  >1 publications with CLASP1 and Mammary Gland
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