EFNB2 Antibody – Rabbit Polyclonal

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

EFNB2: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons

Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q33

Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane

Molecular Function: ephrin receptor binding; protein binding; viral receptor activity

Biological Process: anatomical structure morphogenesis; axon guidance; cell adhesion; cell migration during sprouting angiogenesis; cell-cell signaling; entry of virus into host cell; ephrin receptor signaling pathway; lymph vessel development; organ morphogenesis; regulation of chemotaxis; T cell costimulation