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CD75 / ST6GAL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249517

ST6GAL1 Antibody, Alpha 2,6-ST 1 Antibody, Sialyltransferase 1 Antibody, SIAT1 Antibody, ST6Gal I Antibody, ST6GalI Antibody, ST6N Antibody, B-cell antigen CD75 Antibody, CD75 Antibody Description: CD75 / ST6GAL1 is a member of glycosyltransferase family 29.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CD75 / ST6GAL1, Polyclonal Antibody
Full Product Name
Anti-CD75 / ST6GAL1 Antibody (aa178-206) IHC-plus
Product Gene Name
anti-CD75 / ST6GAL1 antibody
Product Synonym Names
Rabbit Polyclonal to Human CD75 / ST6GAL1; Human CD75 / ST6GAL1; Alpha 2,6-ST 1; Sialyltransferase 1; SIAT1; ST6Gal I; ST6GalI; ST6N; B-cell antigen CD75
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity purified
Specificity
Human CD75 / ST6GAL1
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
20,764 Da
OMIM
109675
3D Structure
ModBase 3D Structure for P15907
Immunogen
CD75 / ST6GAL1 antibody was raised against kLH-conjugated synthetic peptide from internal region of human ST6GAL1.
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human ST6GAL1.
Immunogen Type
Synthetic peptide
Antigen Modification
aa178-206
Target Species
Human
Applications Tested/Suitable for anti-CD75 / ST6GAL1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-CD75 / ST6GAL1 antibody
IHC-P (1:75)
WB (1:1000)

Immunohistochemistry (IHC) of anti-CD75 / ST6GAL1 antibody

Anti-CD75 / ST6GAL1 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Rabbit Anti-CD75 / ST6GAL1 Polyclonal Antibody – Cat# MBS249517

Western Blot (WB) of anti-CD75 / ST6GAL1 antibody

ST6GAL1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The ST6GAL1 antibody detected the ST6GAL1 protein (arrow).
Rabbit Anti-CD75 / ST6GAL1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249517

Other Notes

Small volumes of anti-CD75 / ST6GAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD75 / ST6GAL1 purchase

MBS249517 is an antibody targeting CD75 / ST6GAL1. Also known as Anti-CD75 / ST6GAL1 Antibody (aa178-206) IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD75 / ST6GAL1. It may not necessarily be applicable to this product.

NCBI GI #
27765091
NCBI GeneID
6480
NCBI Accession #
NP_775323.1
UniProt Primary Accession #
P15907
UniProt Secondary Accession #
A8KA14; B2R513; D3DNV3
UniProt Related Accession #
P15907
GenBank Nucleotide #
NM_173216.2
NCBI Official Full Name
beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NCBI Official Synonym Full Names
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
NCBI Official Symbol
ST6GAL1
NCBI Official Synonym Symbols
ST6N; SIAT1; ST6GalI
UniProt Protein Name
Beta-galactoside alpha-2,6-sialyltransferase 1
UniProt Synonym Protein Names
B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1
UniProt Gene Name
ST6GAL1
UniProt Synonym Gene Names
SIAT1; Alpha 2,6-ST 1; ST6GalI
UniProt Entry Name
SIAT1_HUMAN
NCBI Protein Information
beta-galactoside alpha-2,6-sialyltransferase 1

NCBI Summary for CD75 / ST6GAL1

This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]
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UniProt Comments for CD75 / ST6GAL1

SIAT1: a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Is normally found in the trans cisternae of the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found.

Protein type: Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; EC 2.4.99.1; Transferase

Chromosomal Location of Human Ortholog: 3q27.3

Cellular Component: endoplasmic reticulum; Golgi medial cisterna; Golgi membrane; Golgi trans cisterna; integral to Golgi membrane

Molecular Function: beta-galactoside alpha-2,6-sialyltransferase activity; protein binding; sialyltransferase activity

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; humoral immune response; N-acetylneuraminate metabolic process; negative regulation of chemotaxis; O-glycan processing; oligosaccharide metabolic process; positive regulation of mononuclear cell proliferation; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein amino acid O-linked glycosylation; response to ethanol
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Research Articles on CD75 / ST6GAL1

1. Data indicate that O-glycan-specific alpha2,6 sialyltransferase regulate cancer growth and metastasis by regulating galectins Gal-1- and Gal-3-binding moieties on O-glycans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD75 / ST6GAL1 antibody

 Reference Product  PubMed Publications
 B4GALT1 antibody  >3 publications with CD75 / ST6GAL1 and B4GALT1
 MUC7 antibody  >1 publications with CD75 / ST6GAL1 and MUC7

Pathways associated with anti-CD75 / ST6GAL1 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Antennae Elongation Pathway antibodies  N-Glycan Antennae Elongation Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Antennae Elongation In The Medial/trans-Golgi Pathway antibodies  N-glycan Antennae Elongation In The Medial/trans-Golgi Pathway Diagram
 N-glycan Biosynthesis, Complex Type Pathway antibodies  N-glycan Biosynthesis, Complex Type Pathway Diagram
 N-glycan Biosynthesis, Complex Type Pathway antibodies  N-glycan Biosynthesis, Complex Type Pathway Diagram

Diseases associated with anti-CD75 / ST6GAL1 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >14 publications with CD75 / ST6GAL1 and Neoplasm Metastasis
 Liver Diseases Antibodies  >11 publications with CD75 / ST6GAL1 and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with CD75 / ST6GAL1 and Liver Neoplasms
 Inflammation Antibodies  >8 publications with CD75 / ST6GAL1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >5 publications with CD75 / ST6GAL1 and Carcinoma, Hepatocellular
 Diabetes Mellitus Antibodies  >5 publications with CD75 / ST6GAL1 and Diabetes Mellitus
 Kidney Diseases Antibodies  >4 publications with CD75 / ST6GAL1 and Kidney Diseases
 Breast Neoplasms Antibodies  >4 publications with CD75 / ST6GAL1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with CD75 / ST6GAL1 and Cell Transformation, Neoplastic
 Diabetes Mellitus, Type 2 Antibodies  >3 publications with CD75 / ST6GAL1 and Diabetes Mellitus, Type 2

Organs/Tissues associated with anti-CD75 / ST6GAL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with CD75 / ST6GAL1 and Blood
 Liver Antibodies  >17 publications with CD75 / ST6GAL1 and Liver
 Lymph Antibodies  >10 publications with CD75 / ST6GAL1 and Lymph
 Lymph Node Antibodies  >10 publications with CD75 / ST6GAL1 and Lymph Node
 Lung Antibodies  >9 publications with CD75 / ST6GAL1 and Lung
 Vascular Antibodies  >6 publications with CD75 / ST6GAL1 and Vascular
 Stomach Antibodies  >6 publications with CD75 / ST6GAL1 and Stomach
 Brain Antibodies  >6 publications with CD75 / ST6GAL1 and Brain
 Bone Antibodies  >5 publications with CD75 / ST6GAL1 and Bone
 Kidney Antibodies  >5 publications with CD75 / ST6GAL1 and Kidney
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