TIMP1 Antibody – Rabbit Polyclonal

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp11.3-p11.23

Cellular Component: basement membrane; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: cytokine activity; growth factor activity; metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protein binding

Biological Process: aging; blood coagulation; cartilage development; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of apoptosis; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; platelet activation; platelet degranulation; positive regulation of cell proliferation; response to cytokine stimulus; response to hormone stimulus; response to peptide hormone stimulus