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L1CAM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249582

L1CAM Antibody, CAML1 Antibody, CD171 antigen Antibody, HSAS Antibody, HSAS1 Antibody, MASA Antibody, MIC5 Antibody, N-CAM-L1 Antibody, N-CAML1 Antibody, L1 cell adhesion molecule Antibody, NCAM-L1 Antibody, S10 Antibody, SPG1 Antibody, CD171 Antibody… More details

$650 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
L1CAM, Polyclonal Antibody
Full Product Name
Anti-L1CAM Antibody (aa1153-1182) IHC-plus
Product Gene Name
anti-L1CAM antibody
Product Synonym Names
Rabbit Polyclonal to Human L1CAM; Human L1CAM; CAML1; CD171 antigen; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; L1 cell adhesion molecule; NCAM-L1; S10; SPG1; CD171
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity purified
Specificity
Human L1CAM
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
138,908 Da
OMIM
303350
3D Structure
ModBase 3D Structure for P32004
Immunogen
L1CAM antibody was raised against kLH-conjugated synthetic peptide from C-terminal region of human L1CAM.
Immunogen Description
KLH-conjugated synthetic peptide from C-terminal region of human L1CAM.
Immunogen Type
Synthetic peptide
Antigen Modification
aa1153-1182
Target Species
Human
Applications Tested/Suitable for anti-L1CAM antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-L1CAM antibody
IHC-P (1:100)
WB (1:1000)

Immunohistochemistry (IHC) of anti-L1CAM antibody

Anti-L1CAM antibody IHC staining of human peripheral nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-L1CAM Polyclonal Antibody – Cat# MBS249582

Western Blot (WB) of anti-L1CAM antibody

L1CAM Antibody western blot of Jurkat cell line lysates (35 ug/lane). The L1CAM antibody detected the L1CAM protein (arrow).
Rabbit Anti-L1CAM Polyclonal Antibody, Western Blot (WB) – Cat# MBS249582

Western Blot (WB) of anti-L1CAM antibody

L1CAM Antibody western blot of mouse cerebellum tissue lysates (35 ug/lane). The L1CAM antibody detected the L1CAM protein (arrow).
Rabbit Anti-L1CAM Polyclonal Antibody, Western Blot (WB) – Cat# MBS249582

Other Notes

Small volumes of anti-L1CAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L1CAM purchase

MBS249582 is an antibody targeting L1CAM. Also known as Anti-L1CAM Antibody (aa1153-1182) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for L1CAM. It may not necessarily be applicable to this product.

NCBI GI #
4557707
NCBI GeneID
3897
NCBI Accession #
NP_000416.1
UniProt Primary Accession #
P32004
UniProt Secondary Accession #
Q8TA87; A0AV65; A4ZYW4; B2RMU7; G3XAF4
UniProt Related Accession #
P32004
GenBank Nucleotide #
NM_000425.4
NCBI Official Full Name
neural cell adhesion molecule L1 isoform 1
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
Protein Family
Neural cell adhesion molecule
UniProt Gene Name
L1CAM
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1
UniProt Entry Name
L1CAM_HUMAN
NCBI Protein Information
neural cell adhesion molecule L1

NCBI Summary for L1CAM

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
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UniProt Comments for L1CAM

NCAM-L1: cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. Two splice-variant isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cell surface; external side of plasma membrane; focal adhesion; integral to membrane; plasma membrane; presynaptic membrane; terminal button

Molecular Function: identical protein binding; integrin binding; protein self-association; sialic acid binding

Biological Process: axon guidance; blood coagulation; cell adhesion; cell surface receptor linked signal transduction; cell-cell adhesion mediated by integrin; chemotaxis; heterophilic cell adhesion; homophilic cell adhesion; homotypic cell-cell adhesion; leukocyte adhesion; leukocyte migration; nervous system development; positive regulation of axon extension; positive regulation of calcium-mediated signaling; positive regulation of cell-cell adhesion

Disease: Corpus Callosum, Partial Agenesis Of, X-linked; Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius; Masa Syndrome
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Research Articles on L1CAM

1. Our findings establish Slug-induced L1CAM expression as a mediator of a chemoresistant and migratory phenotype in pancreatic adenocarcinoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-L1CAM antibody

 Reference Product  PubMed Publications
 ANK2 antibody  >8 publications with L1CAM and ANK2
 ATL1 antibody  >2 publications with L1CAM and ATL1
 ANK3 antibody  >1 publications with L1CAM and ANK3
 ANK1 antibody  >1 publications with L1CAM and ANK1

Pathways associated with anti-L1CAM antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram

Diseases associated with anti-L1CAM antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >354 publications with L1CAM and Nervous System Diseases
 Brain Diseases Antibodies  >231 publications with L1CAM and Brain Diseases
 Disease Models, Animal Antibodies  >85 publications with L1CAM and Disease Models, Animal
 Adenocarcinoma Antibodies  >56 publications with L1CAM and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >41 publications with L1CAM and Ovarian Neoplasms
 Movement Disorders Antibodies  >26 publications with L1CAM and Movement Disorders
 Neoplasms, Experimental Antibodies  >25 publications with L1CAM and Neoplasms, Experimental
 Nerve Degeneration Antibodies  >24 publications with L1CAM and Nerve Degeneration
 Aphasia Antibodies  >24 publications with L1CAM and Aphasia
 Kidney Diseases Antibodies  >22 publications with L1CAM and Kidney Diseases

Organs/Tissues associated with anti-L1CAM antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >861 publications with L1CAM and Brain
 Nerve Antibodies  >474 publications with L1CAM and Nerve
 Embryonic Tissue Antibodies  >111 publications with L1CAM and Embryonic Tissue
 Ganglia Antibodies  >68 publications with L1CAM and Ganglia
 Eye Antibodies  >61 publications with L1CAM and Eye
 Muscle Antibodies  >49 publications with L1CAM and Muscle
 Kidney Antibodies  >41 publications with L1CAM and Kidney
 Skin Antibodies  >34 publications with L1CAM and Skin
 Lung Antibodies  >33 publications with L1CAM and Lung
 Liver Antibodies  >32 publications with L1CAM and Liver
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