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IFITM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249658

IFITM2 Antibody, 1-8D Antibody, Dispanin subfamily A member 2c Antibody, DSPA2c Antibody Description: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IFITM2, Polyclonal Antibody
Full Product Name
Anti-IFITM2 Antibody (aa6-35) IHC-plus
Product Gene Name
anti-IFITM2 antibody
Product Synonym Names
Rabbit Polyclonal to Human IFITM2; Human IFITM2; 1-8D; Dispanin subfamily A member 2c; DSPA2c
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity purified
Specificity
Human IFITM2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
14,632 Da
OMIM
605578
3D Structure
ModBase 3D Structure for Q01629
Immunogen
IFITM2 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human IFM2.
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human IFM2.
Immunogen Type
Synthetic peptide
Antigen Modification
aa6-35
Target Species
Human
Applications Tested/Suitable for anti-IFITM2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-IFITM2 antibody
IHC-P (5 ug/ml)
WB (1:1000)

Immunohistochemistry (IHC) of anti-IFITM2 antibody

Anti-IFITM2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-IFITM2 Polyclonal Antibody – Cat# MBS249658

Western Blot (WB) of anti-IFITM2 antibody

Western blot of IFM2 Antibody in NCI-H460 cell line lysates (35 ug/lane). IFM2 (arrow) was detected using the purified antibody.
Rabbit Anti-IFITM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249658

Other Notes

Small volumes of anti-IFITM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFITM2 purchase

MBS249658 is an antibody targeting IFITM2. Also known as Anti-IFITM2 Antibody (aa6-35) IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFITM2. It may not necessarily be applicable to this product.

NCBI GI #
151101191
NCBI GeneID
10581
NCBI Accession #
NP_006426.2
UniProt Primary Accession #
Q01629
UniProt Secondary Accession #
Q6FH82; Q96DA8
UniProt Related Accession #
Q01629
GenBank Nucleotide #
NM_006435.2
NCBI Official Full Name
interferon-induced transmembrane protein 2
NCBI Official Synonym Full Names
interferon induced transmembrane protein 2
NCBI Official Symbol
IFITM2
NCBI Official Synonym Symbols
1-8D; DSPA2c
UniProt Protein Name
Interferon-induced transmembrane protein 2
UniProt Synonym Protein Names
Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D
Protein Family
Interferon-induced transmembrane protein
UniProt Gene Name
IFITM2
UniProt Synonym Gene Names
DSPA2c
UniProt Entry Name
IFM2_HUMAN
NCBI Protein Information
interferon-induced transmembrane protein 2

UniProt Comments for IFITM2

IFITM2: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Belongs to the CD225/Dispanin family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: integral to membrane; plasma membrane

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; immune response; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus
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Research Articles on IFITM2

1. G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFITM2 antibody

 Reference Product  PubMed Publications
 IFI6 antibody  >2 publications with IFITM2 and IFI6
 ISG20 antibody  >1 publications with IFITM2 and ISG20
 IFI35 antibody  >1 publications with IFITM2 and IFI35
 IFIT3 antibody  >1 publications with IFITM2 and IFIT3
 IFIT1 antibody  >1 publications with IFITM2 and IFIT1

Pathways associated with anti-IFITM2 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram

Diseases associated with anti-IFITM2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with IFITM2 and Inflammation
 Adenocarcinoma Antibodies  >2 publications with IFITM2 and Adenocarcinoma
 Necrosis Antibodies  >2 publications with IFITM2 and Necrosis
 Nervous System Diseases Antibodies  >1 publications with IFITM2 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with IFITM2 and Brain Diseases
 Heart Diseases Antibodies  >1 publications with IFITM2 and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with IFITM2 and Cell Transformation, Neoplastic
 Weight Loss Antibodies  >1 publications with IFITM2 and Weight Loss

Organs/Tissues associated with anti-IFITM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with IFITM2 and Blood
 Brain Antibodies  >4 publications with IFITM2 and Brain
 Bone Antibodies  >2 publications with IFITM2 and Bone
 Embryonic Tissue Antibodies  >2 publications with IFITM2 and Embryonic Tissue
 Heart Antibodies  >2 publications with IFITM2 and Heart
 Lung Antibodies  >2 publications with IFITM2 and Lung
 Tonsil Antibodies  >1 publications with IFITM2 and Tonsil
 Spleen Antibodies  >1 publications with IFITM2 and Spleen
 Kidney Antibodies  >1 publications with IFITM2 and Kidney
 Muscle Antibodies  >1 publications with IFITM2 and Muscle
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