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ETHE1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249683

ETHE1 Antibody, D83198 Antibody, Ethylmalonic encephalopathy 1 Antibody, HSCO Antibody, YF13H12 Antibody, Protein ETHE1, mitochondrial Antibody Description: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ETHE1, Polyclonal Antibody
Full Product Name
Anti-ETHE1 Antibody (aa180-209) IHC-plus
Product Gene Name
anti-ETHE1 antibody
Product Synonym Names
Rabbit Polyclonal to Human ETHE1; Human ETHE1; D83198; Ethylmalonic encephalopathy 1; HSCO; YF13H12; Protein ETHE1; mitochondrial
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Ammonium sulfate precipitation
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
27,873 Da
OMIM
602473
3D Structure
ModBase 3D Structure for O95571
Immunogen
ETHE1 antibody was raised against kLH conjugated synthetic peptide selected from the C-terminal region of human ETHE1.
Immunogen Description
KLH conjugated synthetic peptide selected from the C-terminal region of human ETHE1.
Immunogen Type
Synthetic peptide
Antigen Modification
aa180-209
Target Species
Human
Applications Tested/Suitable for anti-ETHE1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-ETHE1 antibody
IHC-P (1:100)
WB (1:1000)

Immunohistochemistry (IHC) of anti-ETHE1 antibody

Anti-ETHE1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-ETHE1 Polyclonal Antibody – Cat# MBS249683

Western Blot (WB) of anti-ETHE1 antibody

Western blot of ETHE1 Antibody in mouse liver tissue lysates (35 ug/lane). ETHE1 (arrow) was detected using the purified antibody.
Rabbit Anti-ETHE1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249683

Other Notes

Small volumes of anti-ETHE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ETHE1 purchase

MBS249683 is an antibody targeting ETHE1. Also known as Anti-ETHE1 Antibody (aa180-209) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ETHE1. It may not necessarily be applicable to this product.

NCBI GI #
41327741
NCBI GeneID
23474
NCBI Accession #
NP_055112.2
UniProt Primary Accession #
O95571
UniProt Secondary Accession #
Q96HR0; Q9H001
UniProt Related Accession #
O95571
GenBank Nucleotide #
NM_014297.3
NCBI Official Full Name
persulfide dioxygenase ETHE1, mitochondrial
NCBI Official Synonym Full Names
ethylmalonic encephalopathy 1
NCBI Official Symbol
ETHE1
NCBI Official Synonym Symbols
HSCO; YF13H12
UniProt Protein Name
Persulfide dioxygenase ETHE1, mitochondrial
UniProt Synonym Protein Names
Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1
Protein Family
Persulfide dioxygenase
UniProt Gene Name
ETHE1
UniProt Synonym Gene Names
HSCO
UniProt Entry Name
ETHE1_HUMAN
NCBI Protein Information
persulfide dioxygenase ETHE1, mitochondrial

NCBI Summary for ETHE1

This gene encodes a sulfur dioxygenase that localizes within the mitochondrial matrix. The enzyme functions in sulfide catabolism. Mutations in this gene result in ethylmalonic encephalopathy.[provided by RefSeq, May 2009]

UniProt Comments for ETHE1

ETHE1: Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53- induced apoptosis by preventing nuclear localization of RELA. Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE). EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Protein type: EC 1.13.11.18; Mitochondrial; Hydrolase

Chromosomal Location of Human Ortholog: 19q13.31

Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm

Molecular Function: iron ion binding; sulfur dioxygenase activity

Biological Process: glutathione metabolic process; sulfur amino acid catabolic process; sulfur amino acid metabolic process

Disease: Encephalopathy, Ethylmalonic
Show more

Research Articles on ETHE1

1. ETHE1 R163W/R163Q mutations are associated with Ethylmalonic encephalopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ETHE1 antibody

 Reference Product  PubMed Publications
 SQRDL antibody  >2 publications with ETHE1 and SQRDL
 HDAC1 antibody  >1 publications with ETHE1 and HDAC1
 RELA antibody  >1 publications with ETHE1 and RELA

Pathways associated with anti-ETHE1 antibody

 Products by Pathway  Pathway Diagram
 Degradation Of Cysteine And Homocysteine Pathway antibodies  Degradation Of Cysteine And Homocysteine Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Sulfide Oxidation To Sulfate Pathway antibodies  Sulfide Oxidation To Sulfate Pathway Diagram
 Sulfur Amino Acid Metabolism Pathway antibodies  Sulfur Amino Acid Metabolism Pathway Diagram
 Sulfur Metabolism Pathway antibodies  Sulfur Metabolism Pathway Diagram
 Sulfur Metabolism Pathway antibodies  Sulfur Metabolism Pathway Diagram

Diseases associated with anti-ETHE1 antibody

 Disease Name  Pubmed Publications
 Ethylmalonic encephalopathy Antibodies  >39 publications with ETHE1 and Ethylmalonic encephalopathy
 Nervous System Diseases Antibodies  >22 publications with ETHE1 and Nervous System Diseases
 Blood Coagulation Disorders Antibodies  >11 publications with ETHE1 and Blood Coagulation Disorders
 Hemorrhage Antibodies  >11 publications with ETHE1 and Hemorrhage
 Liver Diseases Antibodies  >4 publications with ETHE1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >3 publications with ETHE1 and Cardiovascular Diseases
 Fatty Liver Antibodies  >3 publications with ETHE1 and Fatty Liver
 Atrophy Antibodies  >2 publications with ETHE1 and Atrophy
 Adenocarcinoma Antibodies  >1 publications with ETHE1 and Adenocarcinoma
 Kidney Diseases Antibodies  >1 publications with ETHE1 and Kidney Diseases

Organs/Tissues associated with anti-ETHE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with ETHE1 and Brain
 Muscle Antibodies  >8 publications with ETHE1 and Muscle
 Blood Antibodies  >8 publications with ETHE1 and Blood
 Skin Antibodies  >4 publications with ETHE1 and Skin
 Kidney Antibodies  >3 publications with ETHE1 and Kidney
 Connective Tissue Antibodies  >1 publications with ETHE1 and Connective Tissue
 Intestine Antibodies  >1 publications with ETHE1 and Intestine
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