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INTS2 / INT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249709

INTS2 Antibody, Integrator complex subunit 2 Antibody, INT2 Antibody, KIAA1287 Antibody Description: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
INTS2 / INT2, Polyclonal Antibody
Full Product Name
Anti-INTS2 / INT2 Antibody (aa201-250) IHC-plus
Product Synonym Names
Rabbit Polyclonal (IgG) to Human INTS2 / INT2; Human INTS2 / INT2; Integrator complex subunit 2; KIAA1287
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
INTS2 Antibody detects endogenous levels of total INTS2 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
134,323 Da
OMIM
611346
3D Structure
ModBase 3D Structure for Q9H0H0
Immunogen
INTS2 / INT2 antibody was raised against synthetic peptide from human INTS2 (aa201-250).
Immunogen Description
Synthetic peptide from human INTS2 (aa201-250).
Antigen Modification
aa201-250
Target Species
Human
Applications Tested/Suitable for anti-INTS2 / INT2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-INTS2 / INT2 antibody
ELISA (1:20000)
IHC-P (10 ug/ml)
WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-INTS2 / INT2 antibody

Anti-INTS2 / INT2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-INTS2 / INT2 Polyclonal Antibody – Cat# MBS249709

Western Blot (WB) of anti-INTS2 / INT2 antibody

Western blot of extracts from RAW264.7 cells, using INTS2 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-INTS2 / INT2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249709

Other Notes

Small volumes of anti-INTS2 / INT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INTS2 / INT2 purchase

MBS249709 is an antibody targeting INTS2 / INT2. Also known as Anti-INTS2 / INT2 Antibody (aa201-250) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INTS2 / INT2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Integrator complex subunit 2
NCBI Official Synonym Full Names
integrator complex subunit 2
NCBI Official Symbol
INTS2
NCBI Official Synonym Symbols
INT2; KIAA1287
UniProt Protein Name
Integrator complex subunit 2
UniProt Gene Name
INTS2
UniProt Synonym Gene Names
KIAA1287; Int2
UniProt Entry Name
INT2_HUMAN
NCBI Protein Information
integrator complex subunit 2

NCBI Summary for INTS2 / INT2

INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
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UniProt Comments for INTS2 / INT2

INTS2: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 2 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: integral to membrane; integrator complex; intracellular; membrane; nuclear membrane

Molecular Function: protein binding

Biological Process: snRNA processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-INTS2 / INT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with INTS2 / INT2 and Brain
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