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Vasohibin 1 / VASH1 (VASH1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249715

VASH1 Antibody, KIAA1036 Antibody, VASH Antibody, Vasohibin 1 Antibody, Vasohibin-1 Antibody Description: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is… More details

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Technical Datasheet View PDF
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Product Overview

Product Name
Vasohibin 1 / VASH1, Polyclonal Antibody
Full Product Name
Anti-Vasohibin 1 / VASH1 Antibody (C-Terminus) IHC-plus
Product Gene Name
anti-VASH1 antibody
Product Synonym Names
Rabbit Polyclonal to Human Vasohibin 1 / VASH1; Human Vasohibin 1 / VASH1; VASH1; KIAA1036; VASH; Vasohibin 1; Vasohibin-1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
Human VASH1. VASH1 antibody is predicted to not cross-react with other vasohibin protein family members. At least two isoforms are known to exist; this antibody will recognize only the long isoform.
Preparation and Storage
Short term 4 degree C
Long term aliquot and store at -20 degree C
Avoid freeze thaw cycles. Store undiluted.
Molecular Weight
21,845 Da
OMIM
609011
3D Structure
ModBase 3D Structure for Q7L8A9
Immunogen
Vasohibin 1 / VASH1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human VASH1
Immunogen Description
A 19 amino acid peptide near the carboxy terminus of human VASH1
Immunogen Type
Synthetic peptide
Antigen Modification
C-Terminus
Target Species
Human
Applications Tested/Suitable for anti-VASH1 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-VASH1 antibody
IF (20 ug/ml)
IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-VASH1 antibody

Anti-Vasohibin 1 / VASH1 antibody IHC staining of human prostate, ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-VASH1 Polyclonal Antibody – Cat# MBS249715

Immunofluorescence (IF) of anti-VASH1 antibody

Immunofluorescence of VASH1 in mouse brain tissue with VASH1 antibody at 20 µg/mL.
Rabbit Anti-VASH1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS249715

Western Blot (WB) of anti-VASH1 antibody

Western blot analysis of VASH1 in human brain tissue lysate with VASH1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-VASH1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249715

Other Notes

Small volumes of anti-VASH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VASH1 purchase

MBS249715 is an antibody targeting VASH1. Also known as Anti-Vasohibin 1 / VASH1 Antibody (C-Terminus) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VASH1. It may not necessarily be applicable to this product.

NCBI GI #
7662454
NCBI GeneID
22846
NCBI Accession #
NP_055724.1
UniProt Primary Accession #
Q7L8A9
UniProt Secondary Accession #
Q96H02; Q9UBF4; Q9Y629
UniProt Related Accession #
Q7L8A9
GenBank Nucleotide #
NM_014909.4
NCBI Official Full Name
vasohibin-1
NCBI Official Synonym Full Names
vasohibin 1
NCBI Official Symbol
VASH1
NCBI Official Synonym Symbols
KIAA1036
UniProt Protein Name
Vasohibin-1
Protein Family
Vasohibin
UniProt Gene Name
VASH1
UniProt Synonym Gene Names
KIAA1036; VASH
UniProt Entry Name
VASH1_HUMAN
NCBI Protein Information
vasohibin-1

UniProt Comments for VASH1

VASH1: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. Belongs to the vasohibin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: apical part of cell; cytoplasm; endoplasmic reticulum; extracellular space

Molecular Function: protein binding

Biological Process: angiogenesis; cell cycle arrest; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of endothelial cell proliferation; response to wounding
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Research Articles on VASH1

1. VASH1 and VASH2 showed distinctive localization and opposing function on the fetoplacental vascularization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VASH1 antibody

 Reference Product  PubMed Publications
 VEGFA antibody  >11 publications with VASH1 and VEGFA
 ANGPTL6 antibody  >1 publications with VASH1 and ANGPTL6

Diseases associated with anti-VASH1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >9 publications with VASH1 and Adenocarcinoma
 Kidney Diseases Antibodies  >7 publications with VASH1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >7 publications with VASH1 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >4 publications with VASH1 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >3 publications with VASH1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >3 publications with VASH1 and Lung Neoplasms
 Inflammation Antibodies  >3 publications with VASH1 and Inflammation
 Hypertrophy Antibodies  >3 publications with VASH1 and Hypertrophy
 Breast Neoplasms Antibodies  >3 publications with VASH1 and Breast Neoplasms
 Fibrosis Antibodies  >2 publications with VASH1 and Fibrosis

Organs/Tissues associated with anti-VASH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >64 publications with VASH1 and Vascular
 Blood Antibodies  >30 publications with VASH1 and Blood
 Eye Antibodies  >8 publications with VASH1 and Eye
 Muscle Antibodies  >7 publications with VASH1 and Muscle
 Lung Antibodies  >6 publications with VASH1 and Lung
 Lymph Node Antibodies  >5 publications with VASH1 and Lymph Node
 Bone Antibodies  >5 publications with VASH1 and Bone
 Embryonic Tissue Antibodies  >4 publications with VASH1 and Embryonic Tissue
 Ovary Antibodies  >2 publications with VASH1 and Ovary
 Placenta Antibodies  >2 publications with VASH1 and Placenta
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