PDX1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]

PDX1: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 13q12.1

Cellular Component: cytosol; nuclear speck

Molecular Function: chromatin binding; protein complex binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; transcription factor binding

Biological Process: central nervous system development; detection of glucose; endocrine pancreas development; exocrine pancreas development; generation of precursor metabolites and energy; glucose homeostasis; glucose metabolic process; gut development; insulin secretion; liver development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction; organ morphogenesis; organ regeneration; organ senescence; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of transcription from RNA polymerase II promoter; response to chlorate; response to cytokine stimulus; response to drug; response to glucocorticoid stimulus; response to iron(II) ion; response to leucine; response to nicotine; response to vitamin; response to wounding; smoothened signaling pathway; stem cell differentiation; transcription from RNA polymerase II promoter

Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal; Maturity-onset Diabetes Of The Young, Type 4; Pancreatic Agenesis 1