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TLX2 / NCX Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249748

TLX2 Antibody, Enx Antibody, Homeobox protein Hox-11L1 Antibody, Neural crest homeobox protein Antibody, Homeo box 11-like 1 Antibody, T-cell leukemia homeobox 2 Antibody, NCX Antibody, HOX11L1 Antibody, T-cell leukemia, homeobox 2 Antibody Description:… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TLX2 / NCX, Polyclonal Antibody
Full Product Name
Anti-TLX2 / NCX Antibody (N-Terminus) IHC-plus
Product Gene Name
Product Synonym Names
Rabbit Polyclonal (IgG) to Human TLX2 / NCX; Human TLX2 / NCX; Enx; Homeobox protein Hox-11L1; Neural crest homeobox protein; Homeo box 11-like 1; T-cell leukemia homeobox 2; HOX11L1; T-cell leukemia; homeobox 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
TLX2 antibody is predicted to not cross-react with other TLX proteins.
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Molecular Weight
30,251 Da
OMIM
604240
3D Structure
ModBase 3D Structure for O43763
Immunogen
TLX2 / NCX antibody was raised against 18 amino acid peptide near the amino terminus of human TLX2.
Immunogen Description
18 amino acid peptide near the amino terminus of human TLX2.
Antigen Modification
N-Terminus
Target Species
Human
Applications Tested/Suitable for anti-TLX2 / NCX antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TLX2 / NCX antibody
IF (20 ug/ml)
IHC-P (10 ug/ml)
WB (0.5 - 1 ug/ml)

Immunohistochemistry (IHC) of anti-TLX2 / NCX antibody

Anti-TLX2 / NCX antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-TLX2 / NCX Polyclonal Antibody – Cat# MBS249748

Immunofluorescence (IF) of anti-TLX2 / NCX antibody

Immunofluorescence of TLX2 in rat brain tissue with TLX2 antibody at 20 ug/ml.
Rabbit Anti-TLX2 / NCX Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS249748

Western Blot (WB) of anti-TLX2 / NCX antibody

Western blot analysis of TLX2 in rat brain tissue lysate with TLX2 antibody at (A) 0.5 and (B) 1 ug/ml.
Rabbit Anti-TLX2 / NCX Polyclonal Antibody, Western Blot (WB) – Cat# MBS249748

Other Notes

Small volumes of anti-TLX2 / NCX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLX2 / NCX purchase

MBS249748 is an antibody targeting TLX2 / NCX. Also known as Anti-TLX2 / NCX Antibody (N-Terminus) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLX2 / NCX. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
T-cell leukemia homeobox protein 2
NCBI Official Synonym Full Names
T-cell leukemia homeobox 2
NCBI Official Symbol
TLX2
NCBI Official Synonym Symbols
NCX; HOX11L1
UniProt Protein Name
T-cell leukemia homeobox protein 2
UniProt Synonym Protein Names
Homeobox protein Hox-11L1; Neural crest homeobox protein
UniProt Gene Name
TLX2
UniProt Synonym Gene Names
HOX11L1; NCX
UniProt Entry Name
TLX2_HUMAN
NCBI Protein Information
T-cell leukemia homeobox protein 2

NCBI Summary for TLX2 / NCX

This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
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UniProt Comments for TLX2 / NCX

TLX2: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: enteric nervous system development; mesoderm formation; negative regulation of dendrite morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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