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PACS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249751

PACS2 Antibody, KIAA0602 Antibody, PACS1-like protein Antibody, PACS-2 Antibody, PACS1L Antibody Description: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PACS2, Polyclonal Antibody
Full Product Name
Anti-PACS2 Antibody (Internal) IHC-plus
Product Gene Name
anti-PACS2 antibody
Product Synonym Names
Rabbit Polyclonal to Human PACS2; Human PACS2; KIAA0602; PACS1-like protein; PACS-2; PACS1L
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
PACS2 antibody is human, mouse and rat reactive. At least three isoforms of PACS2 are known to exist; this antibody will detect all three. PACS2 antibody is predicted to not cross-react with PACS1.
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Molecular Weight
89,609 Da
OMIM
610423
3D Structure
ModBase 3D Structure for Q86VP3
Immunogen
PACS2 antibody was raised against pACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2.
Immunogen Description
PACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2.
Immunogen Type
Synthetic peptide
Antigen Modification
Internal
Target Species
Human
Applications Tested/Suitable for anti-PACS2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-PACS2 antibody
IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)

Immunohistochemistry - Paraffin (IHC) of anti-PACS2 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PACS2 Polyclonal Antibody – Cat# MBS249751

Immunohistochemistry - Paraffin (IHC) of anti-PACS2 antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-PACS2 Polyclonal Antibody, Immunohistochemistry - Paraffin (IHC) – Cat# MBS249751

Other Notes

Small volumes of anti-PACS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PACS2 purchase

MBS249751 is an antibody targeting PACS2. Also known as Anti-PACS2 Antibody (Internal) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PACS2. It may not necessarily be applicable to this product.

NCBI GI #
117949768
NCBI GeneID
23241
NCBI Accession #
Q86VP3.3
UniProt Primary Accession #
Q86VP3
UniProt Secondary Accession #
O60342; Q6P191; Q96FL7; A2VDJ9; G8JLK3
UniProt Related Accession #
Q86VP3
NCBI Official Full Name
Phosphofurin acidic cluster sorting protein 2
NCBI Official Synonym Full Names
phosphofurin acidic cluster sorting protein 2
NCBI Official Symbol
PACS2
NCBI Official Synonym Symbols
PACS-2; PACS1L
UniProt Protein Name
Phosphofurin acidic cluster sorting protein 2
UniProt Synonym Protein Names
PACS1-like protein
Protein Family
Phosphofurin acidic cluster sorting protein
UniProt Gene Name
PACS2
UniProt Synonym Gene Names
KIAA0602; PACS1L; PACS-2
UniProt Entry Name
PACS2_HUMAN
NCBI Protein Information
phosphofurin acidic cluster sorting protein 2

UniProt Comments for PACS2

PACS2: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Belongs to the PACS family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; mitochondrion

Biological Process: apoptosis; autophagic vacuole formation; viral reproduction
Show more

Research Articles on PACS2

1. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PACS2 antibody

 Reference Product  PubMed Publications
 PKD2 antibody  >2 publications with PACS2 and PKD2
 BIRC3 antibody  >1 publications with PACS2 and BIRC3

Diseases associated with anti-PACS2 antibody

 Disease Name  Pubmed Publications
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies  >2 publications with PACS2 and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Necrosis Antibodies  >2 publications with PACS2 and Necrosis
 Kidney Diseases Antibodies  >1 publications with PACS2 and Kidney Diseases
 Hypertrophy Antibodies  >1 publications with PACS2 and Hypertrophy
 Liver Diseases Antibodies  >1 publications with PACS2 and Liver Diseases
 Congenital Abnormalities Antibodies  >1 publications with PACS2 and Congenital Abnormalities

Organs/Tissues associated with anti-PACS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with PACS2 and Liver
 Blood Antibodies  >3 publications with PACS2 and Blood
 Heart Antibodies  >2 publications with PACS2 and Heart
 Kidney Antibodies  >2 publications with PACS2 and Kidney
 Lung Antibodies  >2 publications with PACS2 and Lung
 Muscle Antibodies  >1 publications with PACS2 and Muscle
 Brain Antibodies  >1 publications with PACS2 and Brain
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