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Mannose Receptor / CD206 (CD206) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249782

MRC1 Antibody, BA541I19.1 Antibody, CLEC13D Antibody, CD206 Antibody, CD206 antigen Antibody, Macrophage mannose receptor 1 Antibody, Mannose Receptor Antibody, Macrophage mannose receptor Antibody, MMR Antibody, Mannose receptor, C type 1 Antibody, MRC1L1… More details

$650 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mannose Receptor / CD206, Polyclonal Antibody
Full Product Name
Anti-Mannose Receptor / CD206 Antibody (aa358-388) IHC-plus
Product Gene Name
anti-CD206 antibody
Product Synonym Gene Name
MRC1
Product Synonym Names
Rabbit Polyclonal to Human Mannose Receptor / CD206; Human Mannose Receptor / CD206; MRC1; BA541I19.1; CLEC13D; CD206 antigen; Macrophage mannose receptor 1; Mannose Receptor; Macrophage mannose receptor; MMR; Mannose receptor; C type 1; MRC1L1; CLEC13DL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
P{rotein A purified
Specificity
This MRC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-388 amino acids from the N-terminal region of human MRC1L1.
Preparation and Storage
Maintain refrigerated at 2°C to 8°C for up to 6 months. For long term storage store at -20°C.
OMIM
153618
3D Structure
ModBase 3D Structure for P22897
Immunogen
Mannose Receptor / CD206 antibody was raised against Human
Antigen Modification
aa358-388
Target
Mannose Receptor / CD206
Disclaimer
Due to the highly specific nature of antibodies and antigens, we cannot predict or be held responsible with respect to how this antibody will behave in your systems. Researchers using this antibody should conduct optimization studies to achieve the most optimal result possible for their intended application.
Recommended Immunohistochemistry Protocol
The following protocol is a recommendation only, and MyBioSource, Inc. makes no guarantee of the results:

Tissue Preparation:
Formalin fixation and embedding in paraffin wax.

Tissue Sectioning:
Make 4-um sections and place on pre-cleaned and charged microscope slides. Heat in a tissue-dryingoven for 45 minutes at 60°C.

Deparaffinization:
Wash dry slides in 3 changes of xylene - 5 minutes each @ RT

Rehydration:
Wash slides in 3 changes of 100% alcohol - 3 minutes each @ RT
Wash slides in 2 changes of 95% alcohol - 3 minutes each @ RT
Wash slides in 1 change of 80% alcohol - 3 minutes @ RT
Rinse slides in gentle running distilled water - 5 minutes @ RT

Antigen retrieval:
Steam slides in 0.01 M sodium citrate buffer, pH 6.0 at 99-100°C - 20 minutes
Remove from heat and let stand at room temperature in buffer - 20 minutes
Rinse in 1X TBS with Tween (TBST) -1 minute @ RT

Immunostaining:
(Do not allow tissues to dry at any time during the staining procedure)
Apply a universal protein block - 20 minutes @ RT
Drain protein block from slides, apply diluted primary antibody - 45 minutes @ RT
Rinse slides in 1 X TBST - 1 minute @ RT
Apply a biotinylated secondary antibody appropriate for the primary antibody - 30 minutes @ RT
Rinse slides in 1X TBST -1 minute @ RT
Apply alkaline phosphatase streptavidin - 30 minutes @ RT
Rinse slides in 1X TBST -1 minute @ RT
Apply alkaline phosphatase chromogen substrate - 30 minutes @ RT
Wash slides in distilled water - 1 minute @ RT

Dehydrate:
(This method should only be used if the chromogen substrate is alcohol insoluble (e.g. Vector Red, DAB)
Wash slides in 2 changes of 80% alcohol - 1 minute each @ RT
Wash slides in 2 changes of 95% alcohol - 1 minute each @ RT
Wash slides in 3 changes of 100% alcohol - 1 minute each @ RT
Wash slides in 3 changes of xylene - 1 minute each @ RT
Apply coverslip
Applications Tested/Suitable for anti-CD206 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-CD206 antibody
IHC-P (1:100)
WB (1:1000)

Immunohistochemistry (IHC) of anti-CD206 antibody

Anti-Mannose Receptor / CD206 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-CD206 Polyclonal Antibody – Cat# MBS249782

Western Blot (WB) of anti-CD206 antibody

MRC1L1 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The MRC1L1 antibody detected the MRC1L1 protein (arrow).
Rabbit Anti-CD206 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249782

Other Notes

Small volumes of anti-CD206 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD206 purchase

MBS249782 is an antibody targeting CD206. Also known as Anti-Mannose Receptor / CD206 Antibody (aa358-388) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD206. It may not necessarily be applicable to this product.

NCBI GI #
4505245
NCBI GeneID
4360
NCBI Accession #
NP_002429.1
UniProt Primary Accession #
P22897
UniProt Secondary Accession #
Q5VSJ2; Q5VSK2; A5PKW3
UniProt Related Accession #
P22897
GenBank Nucleotide #
NM_002438.3
NCBI Official Full Name
macrophage mannose receptor 1
NCBI Official Synonym Full Names
mannose receptor, C type 1
NCBI Official Symbol
MRC1
NCBI Official Synonym Symbols
MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
UniProt Protein Name
Macrophage mannose receptor 1
UniProt Synonym Protein Names
C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206
UniProt Gene Name
MRC1
UniProt Synonym Gene Names
CLEC13D; CLEC13DL; MRC1L1; MMR; hMR
UniProt Entry Name
MRC1_HUMAN
NCBI Protein Information
macrophage mannose receptor 1

NCBI Summary for CD206

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
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UniProt Comments for CD206

MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: cell surface; endosome membrane; integral to plasma membrane; plasma membrane

Molecular Function: mannose binding; protein binding; receptor activity; transmembrane receptor activity; viral receptor activity

Biological Process: entry of virus into host cell; receptor-mediated endocytosis; signal transduction
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Research Articles on CD206

1. Data indicate that mannose receptor (CD206) is a major binding receptor for gamma-tilmanocept.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD206 antibody

 Reference Product  PubMed Publications
 CD163 antibody  >15 publications with CD206 and CD163
 CD68 antibody  >14 publications with CD206 and CD68
 ARG1 antibody  >14 publications with CD206 and ARG1
 CCL18 antibody  >6 publications with CD206 and CCL18
 MSR1 antibody  >2 publications with CD206 and MSR1
 ITGAM antibody  >2 publications with CD206 and ITGAM
 ITGAX antibody  >2 publications with CD206 and ITGAX

Pathways associated with anti-CD206 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway antibodies  Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-CD206 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with CD206 and Inflammation
 Nervous System Diseases Antibodies  >22 publications with CD206 and Nervous System Diseases
 Necrosis Antibodies  >11 publications with CD206 and Necrosis
 Lung Diseases Antibodies  >7 publications with CD206 and Lung Diseases
 Disease Models, Animal Antibodies  >6 publications with CD206 and Disease Models, Animal
 Carcinoma Antibodies  >6 publications with CD206 and Carcinoma
 Cardiovascular Diseases Antibodies  >4 publications with CD206 and Cardiovascular Diseases
 Liver Diseases Antibodies  >4 publications with CD206 and Liver Diseases
 Fibrosis Antibodies  >3 publications with CD206 and Fibrosis
 Weight Loss Antibodies  >3 publications with CD206 and Weight Loss

Organs/Tissues associated with anti-CD206 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with CD206 and Blood
 Brain Antibodies  >13 publications with CD206 and Brain
 Lung Antibodies  >6 publications with CD206 and Lung
 Connective Tissue Antibodies  >6 publications with CD206 and Connective Tissue
 Spleen Antibodies  >6 publications with CD206 and Spleen
 Placenta Antibodies  >1 publications with CD206 and Placenta
 Uterus Antibodies  >1 publications with CD206 and Uterus
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