PTGS2 / COX2 / COX-2 Antibody – Rabbit Polyclonal

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family.

Protein type: Oxidoreductase; EC 1.14.99.1; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 1q25.2-q25.3

Cellular Component: caveola; cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; neuron projection; nucleus; protein complex

Molecular Function: arachidonate 15-lipoxygenase activity; enzyme binding; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein binding; protein homodimerization activity

Biological Process: angiogenesis; arachidonic acid metabolic process; bone mineralization; brown fat cell differentiation; cell motility; cyclooxygenase pathway; decidualization; embryo implantation; hair cycle; inflammatory response; learning; lipoxygenase pathway; memory; NAD metabolic process; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; nicotinamide metabolic process; ovulation; positive regulation of apoptosis; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of inflammatory response; response to drug; response to estradiol stimulus; response to fructose stimulus; response to glucocorticoid stimulus; response to lipopolysaccharide; response to lithium ion; response to manganese ion; response to oxidative stress; response to vitamin D; sensory perception of pain; vitamin metabolic process; water-soluble vitamin metabolic process