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MAN2A2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249809

MAN2A2 Antibody, Alpha-mannosidase II Antibody, Alpha-mannosidase 2x Antibody, Man IIx Antibody, MANA2X Antibody, Mannosidase, alpha type II-X Antibody, Alpha-mannosidase IIx Antibody, HsT19662 Antibody Description: Catalyzes the first committed step in the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MAN2A2 / Alpha-Mannosidase II, Polyclonal Antibody
Full Product Name
Anti-MAN2A2 / Alpha-Mannosidase II Antibody (aa766-796) IHC-plus
Product Gene Name
anti-MAN2A2 antibody
Product Synonym Names
Rabbit Polyclonal to Human MAN2A2 / Alpha-Mannosidase II; Human MAN2A2 / Alpha-Mannosidase II; Alpha-mannosidase II; Alpha-mannosidase 2x; Man IIx; MANA2X; Mannosidase; alpha type II-X; Alpha-mannosidase IIx; HsT19662
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity purified
Specificity
Human Alpha-Mannosidase II / MAN2A2
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Molecular Weight
91,059 Da
OMIM
600988
3D Structure
ModBase 3D Structure for P49641
Immunogen
MAN2A2 / Alpha-Mannosidase II antibody was raised against kLH-conjugated synthetic peptide from internal region of human MAN2A2.
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human MAN2A2.
Immunogen Type
Synthetic peptide
Antigen Modification
aa766-796
Target Species
Human
Applications Tested/Suitable for anti-MAN2A2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-MAN2A2 antibody
Flow Cytometry (1:10 - 1:50)
IHC-P (5 ug/ml)
WB (1:1000)

Immunohistochemistry (IHC) of anti-MAN2A2 antibody

Anti-Alpha-Mannosidase II / MAN2A2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MAN2A2 Polyclonal Antibody – Cat# MBS249809

Western Blot (WB) of anti-MAN2A2 antibody

MAN2A2 Antibody western blot of mouse Neuro-2a cell line lysates (35 ug/lane). The MAN2A2 antibody detected the MAN2A2 protein (arrow).
Rabbit Anti-MAN2A2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249809

Flow Cytometry (FC/FACS) of anti-MAN2A2 antibody

MAN2A2 Antibody flow cytometry of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-MAN2A2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249809

Other Notes

Small volumes of anti-MAN2A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAN2A2 purchase

MBS249809 is an antibody targeting MAN2A2. Also known as Anti-MAN2A2 / Alpha-Mannosidase II Antibody (aa766-796) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAN2A2. It may not necessarily be applicable to this product.

NCBI GI #
51477716
NCBI GeneID
4122
NCBI Accession #
NP_006113.2
UniProt Primary Accession #
P49641
UniProt Related Accession #
P49641
GenBank Nucleotide #
NM_006122.2
NCBI Official Full Name
alpha-mannosidase 2x
NCBI Official Synonym Full Names
mannosidase alpha class 2A member 2
NCBI Official Symbol
MAN2A2
NCBI Official Synonym Symbols
MANA2X
UniProt Protein Name
Alpha-mannosidase 2x
UniProt Synonym Protein Names
Alpha-mannosidase IIx; Man IIx; Mannosidase alpha class 2A member 2; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Protein Family
Alpha-mannosidase
UniProt Gene Name
MAN2A2
UniProt Synonym Gene Names
MANA2X; Man IIx
NCBI Protein Information
alpha-mannosidase 2x

UniProt Comments for MAN2A2

MAN2A2: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.114; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Hydrolase

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: alpha-mannosidase activity; carbohydrate binding; hydrolase activity, hydrolyzing N-glycosyl compounds; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; zinc ion binding

Biological Process: cellular protein metabolic process; mannose metabolic process; N-glycan processing; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein deglycosylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MAN2A2 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Antennae Elongation In The Medial/trans-Golgi Pathway antibodies  N-glycan Antennae Elongation In The Medial/trans-Golgi Pathway Diagram
 N-glycan Biosynthesis, Complex Type Pathway antibodies  N-glycan Biosynthesis, Complex Type Pathway Diagram
 N-glycan Biosynthesis, Complex Type Pathway antibodies  N-glycan Biosynthesis, Complex Type Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Reactions Specific To The Complex N-glycan Synthesis Pathway antibodies  Reactions Specific To The Complex N-glycan Synthesis Pathway Diagram

Diseases associated with anti-MAN2A2 antibody

 Disease Name  Pubmed Publications
 Genital Diseases, Male Antibodies  >3 publications with MAN2A2 and Genital Diseases, Male
 Brain Diseases Antibodies  >1 publications with MAN2A2 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with MAN2A2 and Nervous System Diseases

Organs/Tissues associated with anti-MAN2A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with MAN2A2 and Testis
 Brain Antibodies  >1 publications with MAN2A2 and Brain
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