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OASL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249821

OASL Antibody, 2-5-OAS-related protein Antibody, 2-5-OAS-RP Antibody, p59-OASL Antibody, p59OASL Antibody, TR-interacting protein 14 Antibody, TRIP-14 Antibody, TRIP14 Antibody, OASLd Antibody, p59 OASL Antibody Description: Does not have 2'-5'-OAS activity,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
OASL, Polyclonal Antibody
Full Product Name
Anti-OASL Antibody (N-Terminus) IHC-plus
Product Gene Name
anti-OASL antibody
Product Synonym Names
Rabbit Polyclonal to Human OASL; Human OASL; 2-5-OAS-related protein; 2-5-OAS-RP; p59-OASL; p59OASL; TR-interacting protein 14; TRIP-14; TRIP14; OASLd; p59 OASL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
OASL antibody is human, mouse and rat reactive.
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Molecular Weight
43,942 Da
OMIM
603281
3D Structure
ModBase 3D Structure for Q15646
Immunogen
OASL antibody was raised against oASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL.
Immunogen Description
OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL.
Immunogen Type
Synthetic peptide
Antigen Modification
N-Terminus
Target Species
Human
Applications Tested/Suitable for anti-OASL antibody
Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-OASL antibody
ICC (2.5 ug/ml)
IF (20 ug/ml)
IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-OASL antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-OASL Polyclonal Antibody – Cat# MBS249821

Other Notes

Small volumes of anti-OASL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OASL purchase

MBS249821 is an antibody targeting OASL. Also known as Anti-OASL Antibody (N-Terminus) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OASL. It may not necessarily be applicable to this product.

NCBI GI #
11321577
NCBI GeneID
8638
NCBI Accession #
NP_003724.1
UniProt Primary Accession #
Q15646
UniProt Secondary Accession #
O75686; Q17R95; Q9Y6K6; Q9Y6K7; B2RAZ2; I1YDD2
UniProt Related Accession #
Q15646
GenBank Nucleotide #
NM_003733.3
NCBI Official Full Name
2'-5'-oligoadenylate synthase-like protein isoform a
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase-like
NCBI Official Symbol
OASL
NCBI Official Synonym Symbols
OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
UniProt Protein Name
2'-5'-oligoadenylate synthase-like protein
UniProt Synonym Protein Names
2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL
Protein Family
2'-5'-oligoadenylate synthase-like protein
UniProt Gene Name
OASL
UniProt Synonym Gene Names
TRIP14; 2'-5'-OAS-RP; TR-interacting protein 14; TRIP-14; p59OASL
UniProt Entry Name
OASL_HUMAN
NCBI Protein Information
2'-5'-oligoadenylate synthase-like protein

UniProt Comments for OASL

OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1.

Protein type: Nucleolus; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: cytoplasm; cytosol; membrane; nucleolus

Molecular Function: 2'-5'-oligoadenylate synthetase activity; ATP binding; DNA binding; double-stranded RNA binding; thyroid hormone receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; metabolic process; negative regulation of viral genome replication; response to virus
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Research Articles on OASL

1. OASL acts as a cellular antiviral protein and RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OASL antibody

 Reference Product  PubMed Publications
 MX1 antibody  >11 publications with OASL and MX1
 ISG15 antibody  >9 publications with OASL and ISG15
 IRF7 antibody  >7 publications with OASL and IRF7
 IFIT1 antibody  >6 publications with OASL and IFIT1
 IFIT2 antibody  >3 publications with OASL and IFIT2
 IFIT3 antibody  >3 publications with OASL and IFIT3
 RNASEL antibody  >2 publications with OASL and RNASEL
 ISG20 antibody  >1 publications with OASL and ISG20
 MX2 antibody  >1 publications with OASL and MX2

Pathways associated with anti-OASL antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram

Diseases associated with anti-OASL antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >11 publications with OASL and Immune System Diseases
 Hepatitis Antibodies  >11 publications with OASL and Hepatitis
 Nervous System Diseases Antibodies  >8 publications with OASL and Nervous System Diseases
 Inflammation Antibodies  >4 publications with OASL and Inflammation
 Necrosis Antibodies  >2 publications with OASL and Necrosis
 Influenza, Human Antibodies  >2 publications with OASL and Influenza, Human
 Fibrosis Antibodies  >1 publications with OASL and Fibrosis
 Heart Diseases Antibodies  >1 publications with OASL and Heart Diseases
 Proteinuria Antibodies  >1 publications with OASL and Proteinuria
 Kidney Diseases Antibodies  >1 publications with OASL and Kidney Diseases

Organs/Tissues associated with anti-OASL antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with OASL and Blood
 Liver Antibodies  >5 publications with OASL and Liver
 Lung Antibodies  >4 publications with OASL and Lung
 Bone Antibodies  >2 publications with OASL and Bone
 Brain Antibodies  >2 publications with OASL and Brain
 Muscle Antibodies  >1 publications with OASL and Muscle
 Bone Marrow Antibodies  >1 publications with OASL and Bone Marrow
 Prostate Antibodies  >1 publications with OASL and Prostate
 Thyroid Antibodies  >1 publications with OASL and Thyroid
 Intestine Antibodies  >1 publications with OASL and Intestine
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