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CYSLTR1 / CYSLT1 (CYSLT1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249866

CYSLTR1 Antibody, Cys-LT1 receptor Antibody, CysLT(1) Antibody, Cys-leukotriene-1 receptor Antibody, CYSLT1 Antibody, CYSLT1R Antibody, CYSLTR Antibody, HG55 Antibody, LTD4 receptor Antibody, HMTMF81 Antibody, Cysteinyl lt1 receptor Antibody Description:… More details

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Product Overview

Product Name
CYSLTR1 / CYSLT1, Polyclonal Antibody
Full Product Name
Anti-CYSLTR1 / CYSLT1 Antibody (aa131-180) IHC-plus
Product Gene Name
anti-CYSLT1 antibody
Product Synonym Gene Name
CYSLTR1
Product Synonym Names
Rabbit Polyclonal (IgG) to Human CYSLTR1 / CYSLT1; Human CYSLTR1 / CYSLT1; Cys-LT1 receptor; CysLT(1); Cys-leukotriene-1 receptor; CYSLT1; CYSLT1R; CYSLTR; HG55; LTD4 receptor; HMTMF81; Cysteinyl lt1 receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
CYSLTR1 Antibody detects endogenous levels of total CYSLTR1 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
38,541 Da
OMIM
300201
3D Structure
ModBase 3D Structure for Q9Y271
Immunogen
CYSLTR1 / CYSLT1 antibody was raised against synthetic peptide from human CYSLTR1 (aa131-180).
Immunogen Description
Synthetic peptide from human CYSLTR1 (aa131-180).
Antigen Modification
aa131-180
Target Species
Human
Applications Tested/Suitable for anti-CYSLT1 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CYSLT1 antibody
ELISA (1:5000)
IF (1:100 - 1:500)
IHC-P (20 ug/ml)
WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-CYSLT1 antibody

Anti-CYSLTR1 / CYSLT1 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CYSLT1 Polyclonal Antibody – Cat# MBS249866

Immunofluorescence (IF) of anti-CYSLT1 antibody

Immunofluorescence of COS7 cells, using CYSLTR1 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-CYSLT1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS249866

Western Blot (WB) of anti-CYSLT1 antibody

Western blot of extracts from COLO205/HT-29/HeLa cells, using CYSLTR1 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-CYSLT1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249866

Other Notes

Small volumes of anti-CYSLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYSLT1 purchase

MBS249866 is an antibody targeting CYSLT1. Also known as Anti-CYSLTR1 / CYSLT1 Antibody (aa131-180) IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYSLT1. It may not necessarily be applicable to this product.

NCBI GI #
5729798
NCBI GeneID
10800
NCBI Accession #
NP_006630.1
UniProt Primary Accession #
Q9Y271
UniProt Secondary Accession #
Q5JS94; Q8IV19; B2R954; D3DTE4
UniProt Related Accession #
Q9Y271
GenBank Nucleotide #
NM_006639.3
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Symbol
CYSLTR1
NCBI Official Synonym Symbols
CYSLT1; CYSLTR; CYSLT1R; HMTMF81
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Synonym Protein Names
Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
UniProt Gene Name
CYSLTR1
UniProt Synonym Gene Names
CYSLT1; CysLTR1; LTD4 receptor
UniProt Entry Name
CLTR1_HUMAN
NCBI Protein Information
cysteinyl leukotriene receptor 1

NCBI Summary for CYSLT1

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for CYSLT1

CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13.2-q21.1

Cellular Component: cytosol; integral to plasma membrane; membrane; plasma membrane

Molecular Function: cysteinyl leukotriene receptor activity; leukotriene receptor activity; peptide receptor activity, G-protein coupled; protein binding

Biological Process: calcium ion transport; cell surface receptor linked signal transduction; chemotaxis; circulatory system process; defense response; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neuropeptide signaling pathway; respiratory gaseous exchange
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Research Articles on CYSLT1

1. in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYSLT1 antibody

 Reference Product  PubMed Publications
 CYSLTR2 antibody  >15 publications with CYSLT1 and CYSLTR2
 TBXA2R antibody  >5 publications with CYSLT1 and TBXA2R
 GPR17 antibody  >2 publications with CYSLT1 and GPR17

Pathways associated with anti-CYSLT1 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram

Diseases associated with anti-CYSLT1 antibody

 Disease Name  Pubmed Publications
 Asthma Antibodies  >44 publications with CYSLT1 and Asthma
 Lung Diseases, Obstructive Antibodies  >33 publications with CYSLT1 and Lung Diseases, Obstructive
 Lung Diseases Antibodies  >33 publications with CYSLT1 and Lung Diseases
 Inflammation Antibodies  >16 publications with CYSLT1 and Inflammation
 Drug Hypersensitivity Antibodies  >10 publications with CYSLT1 and Drug Hypersensitivity
 Drug-Related Side Effects and Adverse Reactions Antibodies  >8 publications with CYSLT1 and Drug-Related Side Effects and Adverse Reactions
 Asthma, Aspirin-Induced Antibodies  >8 publications with CYSLT1 and Asthma, Aspirin-Induced
 Rhinitis Antibodies  >6 publications with CYSLT1 and Rhinitis
 Necrosis Antibodies  >5 publications with CYSLT1 and Necrosis
 Cardiovascular Diseases Antibodies  >3 publications with CYSLT1 and Cardiovascular Diseases

Organs/Tissues associated with anti-CYSLT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with CYSLT1 and Blood
 Connective Tissue Antibodies  >1 publications with CYSLT1 and Connective Tissue
 Lymph Node Antibodies  >1 publications with CYSLT1 and Lymph Node
 Uterus Antibodies  >1 publications with CYSLT1 and Uterus
 Trachea Antibodies  >1 publications with CYSLT1 and Trachea
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