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CCNL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249869

CCNL2 Antibody, ANIA-6B Antibody, CCNM Antibody, Cyclin M Antibody, HLA-ISO Antibody, PCEE Antibody, SB138 Antibody, Cyclin L2 Antibody, Cyclin-L2 Antibody, HCLA-ISO Antibody Description: CCNL2 / Cyclin L2 belongs to the cyclin family. Through its interaction… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CCNL2 / Cyclin L2, Polyclonal Antibody
Full Product Name
Anti-CCNL2 / Cyclin L2 Antibody (aa345-374) IHC-plus
Product Gene Name
anti-CCNL2 antibody
Product Synonym Names
Rabbit Polyclonal to Human CCNL2 / Cyclin L2; Human CCNL2 / Cyclin L2; ANIA-6B; CCNM; Cyclin M; HLA-ISO; PCEE; SB138; Cyclin L2; Cyclin-L2; HCLA-ISO
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity purified
Specificity
Human Cyclin L2 / CCNL2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
33,839 Da
OMIM
613482
3D Structure
ModBase 3D Structure for Q96S94
Immunogen
CCNL2 / Cyclin L2 antibody was raised against kLH-conjugated synthetic peptide from internal region of human CCNL2.
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human CCNL2.
Immunogen Type
Synthetic peptide
Antigen Modification
aa345-374
Target Species
Human
Applications Tested/Suitable for anti-CCNL2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-CCNL2 antibody
IHC-P (1:75)
WB (1:1000)

Immunohistochemistry (IHC) of anti-CCNL2 antibody

Anti-CCNL2 / Cyclin L2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Rabbit Anti-CCNL2 Polyclonal Antibody – Cat# MBS249869

Western Blot (WB) of anti-CCNL2 antibody

CCNL2 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The CCNL2 antibody detected the CCNL2 protein (arrow).
Rabbit Anti-CCNL2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249869

Other Notes

Small volumes of anti-CCNL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCNL2 purchase

MBS249869 is an antibody targeting CCNL2. Also known as Anti-CCNL2 / Cyclin L2 Antibody (aa345-374) IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCNL2. It may not necessarily be applicable to this product.

NCBI GI #
88758580
NCBI GeneID
81669
NCBI Accession #
NP_112199.2
UniProt Primary Accession #
Q96S94
UniProt Secondary Accession #
Q5T2N5; Q5T2N6; Q6IQ12; Q7Z4Z8; Q8N3C9; Q8N3D5; Q8NHE3; Q8TEL0; Q96B00; A8K8A3; B1B152
UniProt Related Accession #
Q96S94
GenBank Nucleotide #
NM_030937.4
NCBI Official Full Name
cyclin-L2 isoform A
NCBI Official Synonym Full Names
cyclin L2
NCBI Official Symbol
CCNL2
NCBI Official Synonym Symbols
CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO
UniProt Protein Name
Cyclin-L2
UniProt Synonym Protein Names
Paneth cell-enhanced expression protein
Protein Family
Cyclin
UniProt Gene Name
CCNL2
UniProt Entry Name
CCNL2_HUMAN
NCBI Protein Information
cyclin-L2

NCBI Summary for CCNL2

The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for CCNL2

CCNL2: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis. Belongs to the cyclin family. Cyclin L subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Transcription regulation

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: cyclin-dependent protein kinase holoenzyme complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase regulator activity; protein binding; protein kinase binding

Biological Process: positive regulation of cyclin-dependent protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
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Research Articles on CCNL2

1. Therefore, cyclin L2-mediated control of SAMHD1 levels in macrophages supports HIV-1 replication.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCNL2 antibody

 Reference Product  PubMed Publications
 CDK19 antibody  >1 publications with CCNL2 and CDK19
 CSNK2A1 antibody  >1 publications with CCNL2 and CSNK2A1
 CDK11A antibody  >1 publications with CCNL2 and CDK11A
 DYRK1A antibody  >1 publications with CCNL2 and DYRK1A

Diseases associated with anti-CCNL2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with CCNL2 and Brain Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with CCNL2 and Neurodegenerative Diseases
 Nervous System Diseases Antibodies  >2 publications with CCNL2 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with CCNL2 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with CCNL2 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with CCNL2 and Liver Diseases
 Cardiovascular Diseases Antibodies  >1 publications with CCNL2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with CCNL2 and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with CCNL2 and Liver Neoplasms

Organs/Tissues associated with anti-CCNL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with CCNL2 and Lung
 Muscle Antibodies  >1 publications with CCNL2 and Muscle
 Liver Antibodies  >1 publications with CCNL2 and Liver
 Stomach Antibodies  >1 publications with CCNL2 and Stomach
 Intestine Antibodies  >1 publications with CCNL2 and Intestine
 Testis Antibodies  >1 publications with CCNL2 and Testis
 Embryonic Tissue Antibodies  >1 publications with CCNL2 and Embryonic Tissue
 Brain Antibodies  >1 publications with CCNL2 and Brain
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