SREBF2 / SREBP2 Antibody – Rabbit Polyclonal

This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SREBP-2: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. Belongs to the SREBP family.

Protein type: DNA-binding; Membrane protein, integral; Transcription factor; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; nucleoplasm; nucleus

Molecular Function: C-8 sterol isomerase activity; protein binding; protein C-terminus binding; protein dimerization activity

Biological Process: cellular response to starvation; cholesterol metabolic process; lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; response to low density lipoprotein stimulus; transcription, DNA-dependent