PRKCQ / PKC-THETA Antibody – Rabbit Polyclonal

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

PKCT: an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes.

Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; Kinase, protein; AGC group; PKC family; Delta subfamily

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: cytosol; immunological synapse; intracellular; neuromuscular junction; nucleus; plasma membrane; sarcolemma

Molecular Function: ATP binding; metal ion binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; aging; apoptosis; axon guidance; blood coagulation; cell structure disassembly during apoptosis; inflammatory response; innate immune response; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phototransduction, visible light; platelet activation; positive regulation of filopodium formation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of NF-kappaB import into nucleus; positive regulation of protein secretion; positive regulation of stress fiber formation; positive regulation of T cell activation; positive regulation of T cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; programmed cell death; protein ubiquitination; regulation of cell growth; regulation of G2/M transition of mitotic cell cycle; regulation of rhodopsin mediated signaling; regulation of transcription, DNA-dependent; regulation of vasoconstriction; respiratory burst; response to glucose stimulus; response to heat; response to hypoxia; response to insulin stimulus; response to organic cyclic substance; rhodopsin mediated signaling; T cell receptor signaling pathway; tissue regeneration