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CORO1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249940

CORO1A Antibody, Clipin-A Antibody, Coronin-like protein A Antibody, Coronin-like protein p57 Antibody, CLIPINA Antibody, Coronin-1 Antibody, Coronin-1A Antibody, HCORO1 Antibody, p57 Antibody, TACO Antibody, CLABP Antibody, CORO1 Antibody Description: May be… More details

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Product Overview

Product Name
CORO1A / Coronin 1a, Polyclonal Antibody
Full Product Name
Anti-CORO1A / Coronin 1a Antibody IHC-plus
Product Gene Name
anti-CORO1A antibody
Product Synonym Names
Rabbit Polyclonal to Human CORO1A / Coronin 1a; Human CORO1A / Coronin 1a; Clipin-A; Coronin-like protein A; Coronin-like protein p57; CLIPINA; Coronin-1; Coronin-1A; HCORO1; p57; TACO; CLABP; CORO1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat, Human
Purity/Purification
Antiserum
Specificity
Human CORO1A / p57
Preparation and Storage
4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Molecular Weight
51,026 Da
OMIM
605000
3D Structure
ModBase 3D Structure for P31146
Immunogen
CORO1A / Coronin 1a antibody was raised against full length recombinant Coronin 1a expressed in and purified from E Coli.
Immunogen Description
Full length recombinant Coronin 1a expressed in and purified from E Coli.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-CORO1A antibody
Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-CORO1A antibody
ICC (1:5000)
IF (1:500 - 1:1000)
IHC-P (1:100)
WB (1:20000)

Immunohistochemistry (IHC) of anti-CORO1A antibody

Anti-CORO1A / p57 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-CORO1A Polyclonal Antibody – Cat# MBS249940

Immunocytochemistry (ICC) of anti-CORO1A antibody

Immunocytochemistry of a mixed neuron/glial culture from newborn rat brain stained with CORO1A / p57 antibody (green) at a dilution of 1:10,000 and chicken antibody to vimentin. Blue is nuclear DNA counter stain. Glial cells and fibroblasts stain with vimentin, while microglia alone stain strongly and specifically for Coronin 1a, which can therefore be used as a robust marker of this important cell type.
Rabbit Anti-CORO1A Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS249940

Western Blot (WB) of anti-CORO1A antibody

Western blot of HL60 cell extract stained with CORO1A / p57 antibody, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~57kDa corresponds to Coronin 1a. Numbers represent positions of molecular weight standards in kDa.
Rabbit Anti-CORO1A Polyclonal Antibody, Western Blot (WB) – Cat# MBS249940

Other Notes

Small volumes of anti-CORO1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CORO1A purchase

MBS249940 is an antibody targeting CORO1A. Also known as Anti-CORO1A / Coronin 1a Antibody IHC-plus. Reactive in Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CORO1A. It may not necessarily be applicable to this product.

NCBI GI #
5902134
NCBI GeneID
11151
NCBI Accession #
NP_009005.1
UniProt Primary Accession #
P31146
UniProt Secondary Accession #
Q2YD73; B2RBL1
UniProt Related Accession #
P31146
GenBank Nucleotide #
NM_007074.3
NCBI Official Full Name
coronin-1A
NCBI Official Synonym Full Names
coronin 1A
NCBI Official Symbol
CORO1A
NCBI Official Synonym Symbols
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
UniProt Protein Name
Coronin-1A
UniProt Synonym Protein Names
Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
Protein Family
Coronin
UniProt Gene Name
CORO1A
UniProt Synonym Gene Names
CORO1; Clipin-A; TACO
UniProt Entry Name
COR1A_HUMAN
NCBI Protein Information
coronin-1A

NCBI Summary for CORO1A

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
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UniProt Comments for CORO1A

coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: actin filament; axon; cortical actin cytoskeleton; cytoplasm; early endosome; immunological synapse; intercellular junction; lamellipodium; membrane; nucleus; phagocytic cup; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein complex

Molecular Function: actin binding; actin filament binding; actin monomer binding; cytoskeletal protein binding; myosin heavy chain binding; phosphoinositide 3-kinase binding; protein binding; protein C-terminus binding; protein homodimerization activity

Biological Process: actin cytoskeleton organization and biogenesis; actin filament organization; calcium ion transport; cell motility; cell-substrate adhesion; formation of immunological synapse; homeostasis of number of cells within a tissue; innate immune response; leukocyte chemotaxis; natural killer cell degranulation; negative regulation of actin nucleation; negative regulation of neuron apoptosis; negative regulation of vesicle fusion; phagocytosis; phagolysosome formation; positive chemotaxis; positive regulation of cell migration; positive regulation of T cell proliferation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of release of sequestered calcium ion into cytosol; T cell homeostasis; uropod organization and biogenesis

Disease: Immunodeficiency 8
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Research Articles on CORO1A

1. Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CORO1A antibody

 Products by Pathway  Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-CORO1A antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with CORO1A and Disease Models, Animal
 Kidney Diseases Antibodies  >3 publications with CORO1A and Kidney Diseases
 Lung Diseases Antibodies  >1 publications with CORO1A and Lung Diseases
 Breast Neoplasms Antibodies  >1 publications with CORO1A and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with CORO1A and Fibrosis
 Tuberculosis Antibodies  >1 publications with CORO1A and Tuberculosis
 Mammary Neoplasms, Animal Antibodies  >1 publications with CORO1A and Mammary Neoplasms, Animal
 Carcinoma Antibodies  >1 publications with CORO1A and Carcinoma

Organs/Tissues associated with anti-CORO1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with CORO1A and Blood
 Brain Antibodies  >4 publications with CORO1A and Brain
 Bone Antibodies  >3 publications with CORO1A and Bone
 Kidney Antibodies  >3 publications with CORO1A and Kidney
 Bone Marrow Antibodies  >3 publications with CORO1A and Bone Marrow
 Embryonic Tissue Antibodies  >2 publications with CORO1A and Embryonic Tissue
 Skin Antibodies  >2 publications with CORO1A and Skin
 Nerve Antibodies  >2 publications with CORO1A and Nerve
 Thymus Antibodies  >2 publications with CORO1A and Thymus
 Eye Antibodies  >1 publications with CORO1A and Eye
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