HTR2B Antibody – Rabbit Polyclonal

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: cell junction; cell soma; cytoplasm; dendrite; integral to plasma membrane; plasma membrane; synapse

Molecular Function: drug binding; G-protein alpha-subunit binding; GTPase activator activity; serotonin binding; serotonin receptor activity

Biological Process: behavior; calcium-mediated signaling; cellular calcium ion homeostasis; cGMP biosynthetic process; embryonic morphogenesis; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; heart morphogenesis; inositol phosphate metabolic process; intestine smooth muscle contraction; negative regulation of apoptosis; negative regulation of autophagy; neural crest cell differentiation; neural crest cell migration; phosphoinositide 3-kinase cascade; phospholipase C activation; phosphorylation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphatidylinositol biosynthetic process; protein kinase C activation; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; vasoconstriction