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KNG1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249992

KNG1 Antibody, Bradykinin Antibody, Flaujeac factor deficiency Antibody, Fitzgerald factor Antibody, Kininogen 1 Antibody, Kininogen-1 Antibody, Kininogen Antibody, BDK Antibody, HMWK Antibody, KNG Antibody Description: 1 Kininogens are inhibitors of thiol… More details

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Testing Data View PDF
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Product Overview

Product Name
KNG1 / Kininogen / Bradykinin, Polyclonal Antibody
Full Product Name
Anti-KNG1 / Kininogen / Bradykinin Antibody (aa138-166) IHC-plus
Product Gene Name
anti-KNG1 antibody
Product Synonym Names
Rabbit Polyclonal to Human KNG1 / Kininogen / Bradykinin; Human KNG1 / Kininogen / Bradykinin; Bradykinin; Flaujeac factor deficiency; Fitzgerald factor; Kininogen 1; Kininogen-1; Kininogen; BDK; HMWK; KNG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity purified
Specificity
Human Kininogen / Bradykinin
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
43,822 Da
OMIM
228960
3D Structure
ModBase 3D Structure for P01042
Immunogen
KNG1 / Kininogen / Bradykinin antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human KNG1.
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human KNG1.
Immunogen Type
Synthetic peptide
Antigen Modification
aa138-166
Target Species
Human
Applications Tested/Suitable for anti-KNG1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-KNG1 antibody
Flow Cytometry (1:10 - 1:50)
IHC-P (1:100)
WB (1:1000)

Immunohistochemistry (IHC) of anti-KNG1 antibody

Anti-KNG1 / Kininogen / Bradykinin antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-KNG1 Polyclonal Antibody – Cat# MBS249992

Western Blot (WB) of anti-KNG1 antibody

KNG1 Antibody western blot of Ramos cell line lysates (35 ug/lane). The KNG1 antibody detected the KNG1 protein (arrow).
Rabbit Anti-KNG1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249992

Western Blot (WB) of anti-KNG1 antibody

Western blot of KNG1 (arrow) using rabbit polyclonal KNG1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the KNG1 gene.
Rabbit Anti-KNG1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249992

Flow Cytometry (FC/FACS) of anti-KNG1 antibody

KNG1 Antibody flow cytometry of Ramos cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-KNG1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249992

Other Notes

Small volumes of anti-KNG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KNG1 purchase

MBS249992 is an antibody targeting KNG1. Also known as Anti-KNG1 / Kininogen / Bradykinin Antibody (aa138-166) IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KNG1. It may not necessarily be applicable to this product.

NCBI GI #
4504893
NCBI GeneID
3827
NCBI Accession #
NP_000884.1
UniProt Primary Accession #
P01042
UniProt Secondary Accession #
P01043; Q53EQ0; Q6PAU9; Q7M4P1; A8K474; B2RCR2; C9JEX1
UniProt Related Accession #
P01042
GenBank Nucleotide #
NM_000893.3
NCBI Official Full Name
kininogen-1 isoform 2
NCBI Official Synonym Full Names
kininogen 1
NCBI Official Symbol
KNG1
NCBI Official Synonym Symbols
BK; BDK; KNG
UniProt Protein Name
Kininogen-1
UniProt Synonym Protein Names
Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK
Protein Family
Kininogen
UniProt Gene Name
KNG1
UniProt Synonym Gene Names
BDK; KNG; HMWK
UniProt Entry Name
KNG1_HUMAN
NCBI Protein Information
kininogen-1

NCBI Summary for KNG1

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]
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UniProt Comments for KNG1

1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
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Research Articles on KNG1

1. 2 genetic loci (kininogen 1 and kallikrein B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein-kinin system and the RAAS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KNG1 antibody

 Reference Product  PubMed Publications
 F11 antibody  >7 publications with KNG1 and F11
 BDKRB2 antibody  >2 publications with KNG1 and BDKRB2
 NOS3 antibody  >2 publications with KNG1 and NOS3
 KLKB1 antibody  >2 publications with KNG1 and KLKB1
 PLG antibody  >1 publications with KNG1 and PLG
 AGT antibody  >1 publications with KNG1 and AGT
 SERPINE1 antibody  >1 publications with KNG1 and SERPINE1

Pathways associated with anti-KNG1 antibody

 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-KNG1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >13 publications with KNG1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >5 publications with KNG1 and Atherosclerosis
 Heart Diseases Antibodies  >5 publications with KNG1 and Heart Diseases
 Inflammation Antibodies  >3 publications with KNG1 and Inflammation
 Kidney Diseases Antibodies  >2 publications with KNG1 and Kidney Diseases
 Hypertension Antibodies  >2 publications with KNG1 and Hypertension
 Nervous System Diseases Antibodies  >2 publications with KNG1 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with KNG1 and Carcinoma, Hepatocellular
 Seizures Antibodies  >1 publications with KNG1 and Seizures
 Liver Diseases Antibodies  >1 publications with KNG1 and Liver Diseases

Organs/Tissues associated with anti-KNG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with KNG1 and Kidney
 Liver Antibodies  >3 publications with KNG1 and Liver
 Prostate Antibodies  >1 publications with KNG1 and Prostate
 Brain Antibodies  >1 publications with KNG1 and Brain
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