CACNA1D Antibody – Rabbit Polyclonal

This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

CACNA1D: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral

Cellular Component: membrane; cell soma; integral to plasma membrane; apical plasma membrane; dendrite; integral to membrane; plasma membrane; voltage-gated calcium channel complex; nucleus; Z disc; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein binding; metal ion binding; calcium channel activity; high voltage-gated calcium channel activity; ion channel activity; voltage-gated ion channel activity; ankyrin binding; alpha-actinin binding; PDZ domain binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; sensory perception of sound; transport; calcium ion transport; calcium-mediated signaling; activation of CREB transcription factor; ion transport; regulation of calcium ion transport; positive regulation of calcium ion transport; transmembrane transport