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CCDC88A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2520493

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The… More details

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Product Overview

Online Datasheet in PDF
Product Name
CCDC88A, Polyclonal Antibody
Full Product Name
CCDC88A Polyclonal Antibody
Product Gene Name
anti-CCDC88A antibody
Product Synonym Names
APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.7mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
207,797 Da
OMIM
609736
Immunogen
Synthetic peptide of human CCDC88A
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CCDC88A antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CCDC88A antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-CCDC88A antibody

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CCDC88A Polyclonal Antibody at dilution 1:50
Rabbit Anti-CCDC88A Polyclonal Antibody – Cat# MBS2520493

Immunohistochemistry (IHC) of anti-CCDC88A antibody

Immunohistochemistry of paraffin-embedded Human colon cancer tissue using CCDC88A Polyclonal Antibody at dilution 1:50
Rabbit Anti-CCDC88A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2520493

Other Notes

Small volumes of anti-CCDC88A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCDC88A purchase

MBS2520493 is an antibody targeting CCDC88A. Also known as CCDC88A Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCDC88A. It may not necessarily be applicable to this product.

NCBI GI #
219518224
NCBI GeneID
55704
NCBI Accession #
AAI44321.1
UniProt Secondary Accession #
Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5; A1IGE7; B7ZM78; C9JG83
UniProt Related Accession #
Q3V6T2
NCBI Official Full Name
CCDC88A protein
NCBI Official Synonym Full Names
coiled-coil domain containing 88A
NCBI Official Symbol
CCDC88A
NCBI Official Synonym Symbols
APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212
UniProt Protein Name
Girdin
UniProt Synonym Protein Names
Akt phosphorylation enhancer; APE; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; GIV; Girders of actin filament; Hook-related protein 1; HkRP1
Protein Family
Girdin
UniProt Gene Name
CCDC88A
UniProt Synonym Gene Names
; APE; GIV; HkRP1
UniProt Entry Name
GRDN_HUMAN
NCBI Protein Information
girdin; AKT-phosphorylation enhancer; Hook-related protein 1; g alpha-interacting vesicle-associated protein; girders of actin filament; girders of actin filaments

UniProt Comments for CCDC88A

girdin: a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: Golgi apparatus; membrane; lamellipodium; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; plasma membrane; cytoplasmic vesicle; cytosol

Molecular Function: protein kinase B binding; protein homodimerization activity; microtubule binding; actin binding; phosphoinositide binding

Biological Process: lamellipodium biogenesis; cell migration; regulation of protein amino acid phosphorylation; TOR signaling pathway; activation of protein kinase B; regulation of actin cytoskeleton organization and biogenesis; DNA replication; regulation of cell proliferation; regulation of DNA replication
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Research Articles on CCDC88A

1. This study showed that reduction of Girdin, an actin-binding protein, leads to impaired cell migration, adhesion, and invasion of human glioblastoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCDC88A antibody

 Reference Product  PubMed Publications
 AKT1 antibody  >4 publications with CCDC88A and AKT1
 GNAI3 antibody  >3 publications with CCDC88A and GNAI3
 PARD3 antibody  >1 publications with CCDC88A and PARD3
 DISC1 antibody  >1 publications with CCDC88A and DISC1

Diseases associated with anti-CCDC88A antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >13 publications with CCDC88A and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >7 publications with CCDC88A and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >5 publications with CCDC88A and Liver Neoplasms
 Disease Models, Animal Antibodies  >4 publications with CCDC88A and Disease Models, Animal
 Liver Diseases Antibodies  >4 publications with CCDC88A and Liver Diseases
 Inflammation Antibodies  >2 publications with CCDC88A and Inflammation
 Heart Diseases Antibodies  >1 publications with CCDC88A and Heart Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with CCDC88A and Abnormalities, Drug-Induced
 Atherosclerosis Antibodies  >1 publications with CCDC88A and Atherosclerosis
 Lung Diseases Antibodies  >1 publications with CCDC88A and Lung Diseases

Organs/Tissues associated with anti-CCDC88A antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >8 publications with CCDC88A and Liver
 Brain Antibodies  >8 publications with CCDC88A and Brain
 Vascular Antibodies  >4 publications with CCDC88A and Vascular
 Nerve Antibodies  >3 publications with CCDC88A and Nerve
 Lymph Node Antibodies  >3 publications with CCDC88A and Lymph Node
 Lymph Antibodies  >3 publications with CCDC88A and Lymph
 Lung Antibodies  >2 publications with CCDC88A and Lung
 Prostate Antibodies  >2 publications with CCDC88A and Prostate
 Embryonic Tissue Antibodies  >2 publications with CCDC88A and Embryonic Tissue
 Mammary Gland Antibodies  >2 publications with CCDC88A and Mammary Gland
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