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GUCY1A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2520521

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3', 5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GUCY1A3, Polyclonal Antibody
Full Product Name
GUCY1A3 Polyclonal Antibody
Product Gene Name
anti-GUCY1A3 antibody
Product Synonym Names
GUCA3; GC-SA3; GUC1A3; GUCSA3; GUCY1A1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.5mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
70,184 Da
OMIM
139396
Immunogen
Recombinant protein of human GUCY1A3
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GUCY1A3 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-GUCY1A3 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-GUCY1A3 antibody

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using GUCY1A3 Polyclonal Antibody at dilution 1:40
Rabbit Anti-GUCY1A3 Polyclonal Antibody – Cat# MBS2520521

Immunohistochemistry (IHC) of anti-GUCY1A3 antibody

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using GUCY1A3 Polyclonal Antibody at dilution 1:40
Rabbit Anti-GUCY1A3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2520521

Other Notes

Small volumes of anti-GUCY1A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GUCY1A3 purchase

MBS2520521 is an antibody targeting GUCY1A3. Also known as GUCY1A3 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GUCY1A3. It may not necessarily be applicable to this product.

NCBI GI #
374253804
NCBI GeneID
2982
NCBI Accession #
NP_001243378.1
UniProt Secondary Accession #
O43843; Q8TAH3; D3DP19; D6RDW3
UniProt Related Accession #
Q02108
GenBank Nucleotide #
NM_001256449.1
NCBI Official Full Name
guanylate cyclase soluble subunit alpha-3 isoform A
NCBI Official Synonym Full Names
guanylate cyclase 1, soluble, alpha 3
NCBI Official Symbol
GUCY1A3
NCBI Official Synonym Symbols
GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A1
UniProt Protein Name
Guanylate cyclase soluble subunit alpha-3
UniProt Synonym Protein Names
GCS-alpha-1; Soluble guanylate cyclase large subunit
Protein Family
Guanylate cyclase soluble
UniProt Gene Name
GUCY1A3
UniProt Synonym Gene Names
GUC1A3; GUCSA3; GUCY1A1; GCS-alpha-3
UniProt Entry Name
GCYA3_HUMAN
NCBI Protein Information
guanylate cyclase soluble subunit alpha-3; GC-S-alpha-1; GCS-alpha-3; soluble guanylate cyclase large subunit

NCBI Summary for GUCY1A3

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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UniProt Comments for GUCY1A3

GUCY1A3: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Protein type: Lyase; Guanylyl cyclase; EC 4.6.1.2; Receptor, misc.; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 4q31.1-q31.2

Cellular Component: guanylate cyclase complex, soluble

Molecular Function: guanylate cyclase activity; GTP binding; heme binding; receptor activity

Biological Process: cGMP biosynthetic process; relaxation of vascular smooth muscle; positive regulation of cGMP biosynthetic process; blood circulation; regulation of blood pressure; blood coagulation; response to defense-related host nitric oxide production; nitric oxide mediated signal transduction

Disease: Moyamoya Disease 6 With Achalasia
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Research Articles on GUCY1A3

1. Dynamic interplay between hsp90, apo-sGC-beta1, and sGC-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC for signaling cascades.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GUCY1A3 antibody

 Reference Product  PubMed Publications
 GUCY1B3 antibody  >5 publications with GUCY1A3 and GUCY1B3

Pathways associated with anti-GUCY1A3 antibody

 Products by Pathway  Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram

Diseases associated with anti-GUCY1A3 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >5 publications with GUCY1A3 and Hypertension
 Heart Diseases Antibodies  >4 publications with GUCY1A3 and Heart Diseases
 Coronary Artery Disease Antibodies  >3 publications with GUCY1A3 and Coronary Artery Disease
 Nervous System Diseases Antibodies  >2 publications with GUCY1A3 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with GUCY1A3 and Brain Diseases
 Death Antibodies  >2 publications with GUCY1A3 and Death
 Pain Antibodies  >1 publications with GUCY1A3 and Pain
 Heart Defects, Congenital Antibodies  >1 publications with GUCY1A3 and Heart Defects, Congenital
 Kidney Diseases Antibodies  >1 publications with GUCY1A3 and Kidney Diseases
 Inflammation Antibodies  >1 publications with GUCY1A3 and Inflammation

Organs/Tissues associated with anti-GUCY1A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with GUCY1A3 and Brain
 Heart Antibodies  >4 publications with GUCY1A3 and Heart
 Vascular Antibodies  >3 publications with GUCY1A3 and Vascular
 Kidney Antibodies  >2 publications with GUCY1A3 and Kidney
 Prostate Antibodies  >2 publications with GUCY1A3 and Prostate
 Nerve Antibodies  >1 publications with GUCY1A3 and Nerve
 Lung Antibodies  >1 publications with GUCY1A3 and Lung
 Muscle Antibodies  >1 publications with GUCY1A3 and Muscle
 Embryonic Tissue Antibodies  >1 publications with GUCY1A3 and Embryonic Tissue
 Liver Antibodies  >1 publications with GUCY1A3 and Liver
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