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RAP1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2524146

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RAP1B, Polyclonal Antibody
Full Product Name
RAP1B Polyclonal Antibody
Product Gene Name
anti-RAP1B antibody
Product Synonym Names
K-REV, RAL1B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.2mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
16,033 Da
OMIM
179530
3D Structure
ModBase 3D Structure for P61224
Immunogen
Recombinant protein of human RAP1B
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RAP1B antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RAP1B antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-RAP1B antibody

Western Blot analysis of 293T, Jurkat and NIH/3T3 cell using RAP1B Polyclonal Antibody at dilution of 1:550
Rabbit Anti-RAP1B Polyclonal Antibody – Cat# MBS2524146

Immunohistochemistry (IHC) of anti-RAP1B antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer using RAP1B Polyclonal Antibody at dilution of 1:50
Rabbit Anti-RAP1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2524146

Immunohistochemistry (IHC) of anti-RAP1B antibody

Immunohistochemistry of paraffin-embedded Human gastric cancer using RAP1B Polyclonal Antibody at dilution of 1:50
Rabbit Anti-RAP1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2524146

Other Notes

Small volumes of anti-RAP1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAP1B purchase

MBS2524146 is an antibody targeting RAP1B. Also known as RAP1B Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RAP1B. It may not necessarily be applicable to this product.

NCBI GI #
47115315
NCBI GeneID
5908
NCBI Accession #
CAG28617.1
UniProt Primary Accession #
P61224
UniProt Secondary Accession #
P09526; Q502X3; Q5TZR4; Q6DCA1; Q6LES0; B2R5Z2; B4DQI8; B4DW74; B4DW94
UniProt Related Accession #
P61224
NCBI Official Full Name
RAP1B, partial
NCBI Official Synonym Full Names
RAP1B, member of RAS oncogene family
NCBI Official Symbol
RAP1B
NCBI Official Synonym Symbols
K-REV; RAL1B
UniProt Protein Name
Ras-related protein Rap-1b
UniProt Synonym Protein Names
GTP-binding protein smg p21B
Protein Family
Ras-related protein
UniProt Gene Name
RAP1B
UniProt Entry Name
RAP1B_HUMAN
NCBI Protein Information
ras-related protein Rap-1b; GTP-binding protein smg p21B; RAS-related protein RAP1B; Ras family small GTP binding protein RAP1B

UniProt Comments for RAP1B

RAP1B: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein, monomeric, Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: membrane; plasma membrane; lipid particle; intracellular; intercellular junction; cytosol; lipid raft

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein complex binding

Biological Process: cell proliferation; microvillus biogenesis; platelet activation; negative regulation of calcium ion-dependent exocytosis; metabolic process; blood coagulation; Rap protein signal transduction
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Research Articles on RAP1B

1. High concentrations of extracellular adenosine in the tumor microenvironment can chronically activate A2B receptors to suppress Rap1B prenylation and signaling at the cell membrane, resulting in reduced cell-cell contact and promoting cell scattering.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RAP1B antibody

 Reference Product  PubMed Publications
 RAPGEF3 antibody  >6 publications with RAP1B and RAPGEF3
 BRAF antibody  >3 publications with RAP1B and BRAF
 AKT1 antibody  >3 publications with RAP1B and AKT1
 RAPGEF4 antibody  >3 publications with RAP1B and RAPGEF4
 RASSF5 antibody  >2 publications with RAP1B and RASSF5
 APBB1IP antibody  >1 publications with RAP1B and APBB1IP

Pathways associated with anti-RAP1B antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway antibodies  GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-RAP1B antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >13 publications with RAP1B and Carcinoma
 Nervous System Diseases Antibodies  >6 publications with RAP1B and Nervous System Diseases
 Kidney Diseases Antibodies  >6 publications with RAP1B and Kidney Diseases
 Inflammation Antibodies  >4 publications with RAP1B and Inflammation
 Adenocarcinoma Antibodies  >4 publications with RAP1B and Adenocarcinoma
 Immune System Diseases Antibodies  >3 publications with RAP1B and Immune System Diseases
 Neoplasms, Experimental Antibodies  >2 publications with RAP1B and Neoplasms, Experimental
 Nervous System Malformations Antibodies  >2 publications with RAP1B and Nervous System Malformations
 Hypertrophy Antibodies  >2 publications with RAP1B and Hypertrophy
 Carcinoma, Hepatocellular Antibodies  >1 publications with RAP1B and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-RAP1B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >82 publications with RAP1B and Blood
 Vascular Antibodies  >20 publications with RAP1B and Vascular
 Brain Antibodies  >15 publications with RAP1B and Brain
 Muscle Antibodies  >11 publications with RAP1B and Muscle
 Kidney Antibodies  >10 publications with RAP1B and Kidney
 Lung Antibodies  >7 publications with RAP1B and Lung
 Embryonic Tissue Antibodies  >6 publications with RAP1B and Embryonic Tissue
 Thyroid Antibodies  >6 publications with RAP1B and Thyroid
 Bone Antibodies  >6 publications with RAP1B and Bone
 Heart Antibodies  >6 publications with RAP1B and Heart
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