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GAB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2524757

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GAB1, Polyclonal Antibody
Full Product Name
GAB1 Polyclonal Antibody
Product Gene Name
anti-GAB1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.7mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
80,005 Da
OMIM
604439
Immunogen
Recombinant protein of human GAB1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3

Product Categories/Family for anti-GAB1 antibody

Cell Biology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GAB1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-GAB1 antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-GAB1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using GAB1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-GAB1 Polyclonal Antibody – Cat# MBS2524757

Immunohistochemistry (IHC) of anti-GAB1 antibody

Immunohistochemistry of paraffin-embedded Human brain tissue using GAB1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-GAB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2524757

Other Notes

Small volumes of anti-GAB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GAB1 purchase

MBS2524757 is an antibody targeting GAB1. Also known as GAB1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GAB1. It may not necessarily be applicable to this product.

NCBI GI #
46370073
NCBI GeneID
2549
NCBI Accession #
NP_002030.2
UniProt Secondary Accession #
Q4W5G2; Q6P1W2; A8K152
UniProt Related Accession #
Q13480
GenBank Nucleotide #
NM_002039.3
NCBI Official Full Name
GRB2-associated-binding protein 1 isoform b
NCBI Official Synonym Full Names
GRB2-associated binding protein 1
NCBI Official Symbol
GAB1
UniProt Protein Name
GRB2-associated-binding protein 1
UniProt Synonym Protein Names
GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
Protein Family
GPI transamidase component
UniProt Gene Name
GAB1
UniProt Entry Name
GAB1_HUMAN
NCBI Protein Information
GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1

UniProt Comments for GAB1

GAB1: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytosol

Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity

Biological Process: epidermal growth factor receptor signaling pathway; cell proliferation; epidermis development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; insulin receptor signaling pathway; innate immune response; platelet-derived growth factor receptor signaling pathway; response to oxidative stress; regulation of cell migration; activation of JNK activity
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Research Articles on GAB1

1. Endometrial GAB1 protein and mRNA expression are reduced in women with PCOS, suggesting that the endometrium of PCOS women have a defect in insulin signaling due to GAB1 down-regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GAB1 antibody

 Reference Product  PubMed Publications
 GRB2 antibody  >203 publications with GAB1 and GRB2
 MET antibody  >99 publications with GAB1 and MET
 PTPN11 antibody  >90 publications with GAB1 and PTPN11
 EGFR antibody  >56 publications with GAB1 and EGFR
 CRK antibody  >21 publications with GAB1 and CRK
 SHC1 antibody  >10 publications with GAB1 and SHC1
 CRKL antibody  >6 publications with GAB1 and CRKL
 GRAP2 antibody  >2 publications with GAB1 and GRAP2
 PIK3R1 antibody  >1 publications with GAB1 and PIK3R1

Pathways associated with anti-GAB1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Constitutive Signaling By EGFRvIII Pathway antibodies  Constitutive Signaling By EGFRvIII Pathway Diagram
 Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway antibodies  Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with anti-GAB1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >18 publications with GAB1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >15 publications with GAB1 and Lung Diseases
 Vascular Diseases Antibodies  >13 publications with GAB1 and Vascular Diseases
 Breast Neoplasms Antibodies  >13 publications with GAB1 and Breast Neoplasms
 Inflammation Antibodies  >12 publications with GAB1 and Inflammation
 Disease Models, Animal Antibodies  >11 publications with GAB1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >11 publications with GAB1 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >11 publications with GAB1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >8 publications with GAB1 and Nervous System Diseases
 Necrosis Antibodies  >7 publications with GAB1 and Necrosis
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