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SLC22A8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2525130

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SLC22A8, Polyclonal Antibody
Full Product Name
SLC22A8 Polyclonal Antibody
Product Gene Name
anti-SLC22A8 antibody
Product Synonym Names
OAT3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
49,821 Da
OMIM
607581
Immunogen
Synthetic peptide of human SLC22A8
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SLC22A8 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SLC22A8 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-SLC22A8 antibody

Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SLC22A8 Polyclonal Antibody at dilution 1:70
Rabbit Anti-SLC22A8 Polyclonal Antibody – Cat# MBS2525130

Immunohistochemistry (IHC) of anti-SLC22A8 antibody

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SLC22A8 Polyclonal Antibody at dilution 1:70
Rabbit Anti-SLC22A8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2525130

Other Notes

Small volumes of anti-SLC22A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC22A8 purchase

MBS2525130 is an antibody targeting SLC22A8. Also known as SLC22A8 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC22A8. It may not necessarily be applicable to this product.

NCBI GI #
296080734
NCBI GeneID
9376
NCBI Accession #
NP_001171665.1
UniProt Secondary Accession #
O95820; Q59EW9; Q96TC1; B4DPH7; F5GWA8; F5H5J1
UniProt Related Accession #
Q8TCC7
GenBank Nucleotide #
NM_001184736.1
NCBI Official Full Name
solute carrier family 22 member 8 isoform 3
NCBI Official Synonym Full Names
solute carrier family 22 (organic anion transporter), member 8
NCBI Official Symbol
SLC22A8
NCBI Official Synonym Symbols
OAT3
UniProt Protein Name
Solute carrier family 22 member 8
UniProt Synonym Protein Names
Organic anion transporter 3; hOAT3
Protein Family
Solute carrier family
UniProt Gene Name
SLC22A8
UniProt Synonym Gene Names
OAT3; hOAT3
UniProt Entry Name
S22A8_HUMAN
NCBI Protein Information
solute carrier family 22 member 8; hOAT3; organic anion transporter 3

UniProt Comments for SLC22A8

SLC22A8: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein kinase C binding; inorganic anion exchanger activity; organic anion transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity

Biological Process: quaternary ammonium group transport; response to toxin; response to methotrexate; transmembrane transport
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Research Articles on SLC22A8

1. Pemetrexed is a superior substrate to methotrexate for hOAT3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC22A8 antibody

 Reference Product  PubMed Publications
 ABCC4 antibody  >9 publications with SLC22A8 and ABCC4
 ABCC2 antibody  >8 publications with SLC22A8 and ABCC2
 SLCO1B1 antibody  >5 publications with SLC22A8 and SLCO1B1
 ABCC1 antibody  >4 publications with SLC22A8 and ABCC1
 SLCO1B3 antibody  >4 publications with SLC22A8 and SLCO1B3
 SLCO2B1 antibody  >3 publications with SLC22A8 and SLCO2B1
 SLCO4A1 antibody  >1 publications with SLC22A8 and SLCO4A1

Pathways associated with anti-SLC22A8 antibody

 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Organic Anion Transport Pathway antibodies  Organic Anion Transport Pathway Diagram
 Organic Cation/anion/zwitterion Transport Pathway antibodies  Organic Cation/anion/zwitterion Transport Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC22A8 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with SLC22A8 and Kidney Diseases
 Hypertension Antibodies  >3 publications with SLC22A8 and Hypertension
 Liver Diseases Antibodies  >3 publications with SLC22A8 and Liver Diseases
 Brain Diseases Antibodies  >1 publications with SLC22A8 and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with SLC22A8 and Liver Neoplasms
 Inflammation Antibodies  >1 publications with SLC22A8 and Inflammation
 Acute Kidney Injury Antibodies  >1 publications with SLC22A8 and Acute Kidney Injury
 Influenza, Human Antibodies  >1 publications with SLC22A8 and Influenza, Human

Organs/Tissues associated with anti-SLC22A8 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >49 publications with SLC22A8 and Kidney
 Brain Antibodies  >18 publications with SLC22A8 and Brain
 Eye Antibodies  >3 publications with SLC22A8 and Eye
 Uncharacterized Tissue Antibodies  >1 publications with SLC22A8 and Uncharacterized Tissue
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