SDCBP Antibody – Rabbit Polyclonal

syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Vesicle; Cytokine; Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 8q12

Cellular Component: extracellular space; endoplasmic reticulum membrane; focal adhesion; cytosol; cytoskeleton; adherens junction; membrane; cytoplasm; interleukin-5 receptor complex; plasma membrane; melanosome; nucleus; vesicle

Molecular Function: protein C-terminus binding; syndecan binding; identical protein binding; protein homodimerization activity; ephrin receptor binding; protein N-terminus binding; protein binding; interleukin-5 receptor binding; frizzled binding; protein heterodimerization activity; growth factor binding; neurexin binding; cytoskeletal adaptor activity; cell adhesion molecule binding; glycoprotein binding

Biological Process: synaptic transmission; axon guidance; Ras protein signal transduction; ephrin receptor signaling pathway; positive regulation of JNK cascade; actin cytoskeleton organization and biogenesis; protein targeting to membrane; substrate-bound cell migration, cell extension; positive regulation of phosphorylation