HIPK1 Antibody – Rabbit Polyclonal

HIPK1: homeodomain interacting protein kinase 1 is a CMGC kinase of the DYRK family. May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor. 4 alternatively spliced isoforms of the human protein have been described.

Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; CMGC group; DYRK family; HIPK subfamily

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: PML body; cytoplasm; nuclear speck; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: neuron differentiation; anterior/posterior pattern formation; smoothened signaling pathway; positive regulation of angiogenesis; eye development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; embryonic retina morphogenesis in camera-type eye; positive regulation of cell proliferation; embryonic camera-type eye morphogenesis; protein amino acid phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis