AATK Antibody – Rabbit Polyclonal

Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.

Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.11.1; TK group; Lmr family

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: recycling endosome; endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; ATP binding

Biological Process: neuron apoptosis; brain development; negative regulation of axon extension; Rab protein signal transduction