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DCK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2527007

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DCK, Polyclonal Antibody
Full Product Name
DCK Polyclonal Antibody
Product Gene Name
anti-DCK antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
30,519 Da
OMIM
125450
3D Structure
ModBase 3D Structure for P27707
Immunogen
Recombinant protein of human DCK
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DCK antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DCK antibody
WB: 1:200-1:1000
IHC: 1:25-1:100

Western Blot (WB) of anti-DCK antibody

Western Blot analysis of Mouse heart tissue using DCK Polyclonal Antibody at dilution of 1:550
Rabbit Anti-DCK Polyclonal Antibody – Cat# MBS2527007

Immunohistochemistry (IHC) of anti-DCK antibody

Immunohistochemistry of paraffin-embedded Human tonsil using DCK Polyclonal Antibody at dilution of 1:20
Rabbit Anti-DCK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2527007

Other Notes

Small volumes of anti-DCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCK purchase

MBS2527007 is an antibody targeting DCK. Also known as DCK Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DCK. It may not necessarily be applicable to this product.

NCBI GI #
49456707
NCBI GeneID
1633
NCBI Accession #
CAG46674.1
UniProt Primary Accession #
P27707
UniProt Secondary Accession #
Q5TZY7; Q6FI11; B2R8V6
UniProt Related Accession #
P27707
NCBI Official Full Name
DCK, partial
NCBI Official Synonym Full Names
deoxycytidine kinase
NCBI Official Symbol
DCK
UniProt Protein Name
Deoxycytidine kinase
Protein Family
Deoxyadenosine/deoxycytidine kinase
UniProt Gene Name
DCK
UniProt Synonym Gene Names
dCK
UniProt Entry Name
DCK_HUMAN
NCBI Protein Information
deoxycytidine kinase; deoxynucleoside kinase

UniProt Comments for DCK

DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family.

Protein type: EC 2.7.1.74; Nucleotide Metabolism - purine; Kinase, other; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 4q13.3-q21.1

Cellular Component: nucleus; cytosol

Molecular Function: protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; ATP binding

Biological Process: pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; pyrimidine nucleoside salvage; phosphorylation; purine salvage; purine base metabolic process; deoxyribonucleoside monophosphate biosynthetic process
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Research Articles on DCK

1. DCK expression levels are prognostic and had predictive value for sensitivity to 5-FU in pancreatic cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCK antibody

 Reference Product  PubMed Publications
 CDA antibody  >74 publications with DCK and CDA
 ADA antibody  >10 publications with DCK and ADA
 NT5C2 antibody  >8 publications with DCK and NT5C2
 PNP antibody  >8 publications with DCK and PNP
 DCTD antibody  >7 publications with DCK and DCTD

Pathways associated with anti-DCK antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Salvage Pathway antibodies  Purine Salvage Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-DCK antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >59 publications with DCK and Carcinoma
 Pancreatic Neoplasms Antibodies  >39 publications with DCK and Pancreatic Neoplasms
 Lung Neoplasms Antibodies  >29 publications with DCK and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >27 publications with DCK and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >15 publications with DCK and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >11 publications with DCK and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >9 publications with DCK and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >7 publications with DCK and Breast Neoplasms
 Liver Neoplasms Antibodies  >5 publications with DCK and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with DCK and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-DCK antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >107 publications with DCK and Blood
 Lung Antibodies  >42 publications with DCK and Lung
 Brain Antibodies  >26 publications with DCK and Brain
 Liver Antibodies  >21 publications with DCK and Liver
 Bone Marrow Antibodies  >21 publications with DCK and Bone Marrow
 Spleen Antibodies  >15 publications with DCK and Spleen
 Pancreas Antibodies  >9 publications with DCK and Pancreas
 Lymph Antibodies  >8 publications with DCK and Lymph
 Lymph Node Antibodies  >8 publications with DCK and Lymph Node
 Thymus Antibodies  >7 publications with DCK and Thymus
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