PFN1 Antibody – Rabbit Polyclonal

profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.

Protein type: Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: neuron projection; cytoskeleton; focal adhesion; membrane; synapse; nucleus; cytosol

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; Rho GTPase binding; adenyl-nucleotide exchange factor activity; actin binding; receptor binding

Biological Process: positive regulation of DNA metabolic process; platelet activation; negative regulation of actin filament bundle formation; negative regulation of stress fiber formation; positive regulation of viral transcription; negative regulation of actin filament polymerization; platelet degranulation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of stress fiber formation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; actin cytoskeleton organization and biogenesis; blood coagulation

Disease: Amyotrophic Lateral Sclerosis 18