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INPPL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2527202

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling.… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
INPPL1, Polyclonal Antibody
Full Product Name
INPPL1 Polyclonal Antibody
Product Gene Name
anti-INPPL1 antibody
Product Synonym Names
OPSMD; SHIP2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.8mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
138,973 Da
Immunogen
Synthetic peptide of human INPPL1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-INPPL1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-INPPL1 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-INPPL1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using INPPL1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-INPPL1 Polyclonal Antibody – Cat# MBS2527202

Immunohistochemistry (IHC) of anti-INPPL1 antibody

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using INPPL1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-INPPL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2527202

Other Notes

Small volumes of anti-INPPL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INPPL1 purchase

MBS2527202 is an antibody targeting INPPL1. Also known as INPPL1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INPPL1. It may not necessarily be applicable to this product.

NCBI GI #
111185689
NCBI GeneID
16332
NCBI Accession #
AAI19454.1
UniProt Secondary Accession #
O08611; Q0VDX5; Q80YB9; Q9JLL7
UniProt Related Accession #
Q6P549
NCBI Official Full Name
Inppl1 protein, partial
NCBI Official Synonym Full Names
inositol polyphosphate phosphatase-like 1
NCBI Official Symbol
Inppl1
NCBI Official Synonym Symbols
51C; SHIP2
UniProt Protein Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
UniProt Synonym Protein Names
AblSH3-binding protein; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2
Protein Family
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
UniProt Gene Name
Inppl1
UniProt Synonym Gene Names
Ship2; INPPL-1; SH2 domain-containing inositol phosphatase 2; SHIP-2
UniProt Entry Name
SHIP2_MOUSE
NCBI Protein Information
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; INPPL-1; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; ablSH3-binding protein; inositol polyphosphate phosphatase-like protein 1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2

UniProt Comments for INPPL1

SHIP-2: an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.86; Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid

Cellular Component: Golgi apparatus; cytoskeleton; cell projection; membrane; lamellipodium; cytoplasm; plasma membrane

Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; hydrolase activity; inositol-polyphosphate 5-phosphatase activity; SH2 domain binding; actin binding; SH3 domain binding

Biological Process: negative regulation of MAP kinase activity; immune system process; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; glucose metabolic process; actin filament organization; endocytosis; cellular lipid metabolic process; inositol trisphosphate metabolic process; post-embryonic development; response to insulin stimulus; negative regulation of cell proliferation; dephosphorylation; negative regulation of DNA replication; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; cell adhesion; endochondral ossification
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Research Articles on INPPL1

1. These findings suggest that palmitate contributes to SHIP2 overexpression in skeletal muscle via the mechanisms involving the activation of ceramide-JNK and NF-kappaB pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-INPPL1 antibody

 Reference Product  PubMed Publications
 Grb2 antibody  >42 publications with INPPL1 and Grb2
 Pten antibody  >35 publications with INPPL1 and Pten
 Epha2 antibody  >3 publications with INPPL1 and Epha2
 Inpp4b antibody  >2 publications with INPPL1 and Inpp4b
 Itsn1 antibody  >1 publications with INPPL1 and Itsn1

Pathways associated with anti-INPPL1 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram

Diseases associated with anti-INPPL1 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >26 publications with INPPL1 and Immune System Diseases
 Inflammation Antibodies  >10 publications with INPPL1 and Inflammation
 Cardiovascular Diseases Antibodies  >8 publications with INPPL1 and Cardiovascular Diseases
 Skin Diseases Antibodies  >7 publications with INPPL1 and Skin Diseases
 Liver Diseases Antibodies  >7 publications with INPPL1 and Liver Diseases
 Atherosclerosis Antibodies  >6 publications with INPPL1 and Atherosclerosis
 Nervous System Diseases Antibodies  >5 publications with INPPL1 and Nervous System Diseases
 Kidney Diseases Antibodies  >4 publications with INPPL1 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >4 publications with INPPL1 and Neoplasm Metastasis
 Necrosis Antibodies  >4 publications with INPPL1 and Necrosis

Organs/Tissues associated with anti-INPPL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >54 publications with INPPL1 and Other
 Bone Antibodies  >51 publications with INPPL1 and Bone
 Bone Marrow Antibodies  >47 publications with INPPL1 and Bone Marrow
 Muscle Antibodies  >27 publications with INPPL1 and Muscle
 Liver Antibodies  >17 publications with INPPL1 and Liver
 Spleen Antibodies  >14 publications with INPPL1 and Spleen
 Kidney Antibodies  >13 publications with INPPL1 and Kidney
 Lung Antibodies  >10 publications with INPPL1 and Lung
 Heart Antibodies  >9 publications with INPPL1 and Heart
 Brain Antibodies  >9 publications with INPPL1 and Brain
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