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ESPL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2528521

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ESPL1, Polyclonal Antibody
Full Product Name
ESPL1 Polyclonal Antibody
Product Gene Name
anti-ESPL1 antibody
Product Synonym Names
ESP1; SEPA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
233,035 Da
Immunogen
Synthetic peptide of human ESPL1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3

Product Categories/Family for anti-ESPL1 antibody

Cell Biology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ESPL1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ESPL1 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-ESPL1 antibody

Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using ESPL1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-ESPL1 Polyclonal Antibody – Cat# MBS2528521

Immunohistochemistry (IHC) of anti-ESPL1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ESPL1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-ESPL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2528521

Other Notes

Small volumes of anti-ESPL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESPL1 purchase

MBS2528521 is an antibody targeting ESPL1. Also known as ESPL1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESPL1. It may not necessarily be applicable to this product.

NCBI GI #
148877887
NCBI GeneID
105988
NCBI Accession #
AAI45845.1
UniProt Secondary Accession #
A6H6E3
UniProt Related Accession #
P60330
NCBI Official Full Name
Espl1 protein
NCBI Official Synonym Full Names
extra spindle pole bodies 1 (S. cerevisiae)
NCBI Official Symbol
Espl1
NCBI Official Synonym Symbols
SSE; Cerp; ESP1; PRCE; AL024103; AU045071
UniProt Protein Name
Separin
UniProt Synonym Protein Names
Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; Separase
Protein Family
Separin
UniProt Gene Name
Espl1
UniProt Synonym Gene Names
Esp1; Kiaa0165
UniProt Entry Name
ESPL1_MOUSE
NCBI Protein Information
separin; Cut1/ESP1 related protein; caspase-like protein ESPL1; extra spindle poles-like 1 protein; separase

UniProt Comments for ESPL1

separase: a caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Regulated by at least two independent mechanisms. First, it is inactivated via its interaction with securin/PTTG1, which probably covers its active site. Second, phosphorylation inactivates it. It is completely phosphorylated during mitosis and dephosphorylated during anaphase. Two alternatively spliced isoforms have been described.

Protein type: EC 3.4.22.49; Protease

Cellular Component: centrosome; cytoplasm; nucleus

Molecular Function: peptidase activity; hydrolase activity; cysteine-type peptidase activity

Biological Process: mitosis; homologous chromosome segregation; mitotic sister chromatid segregation; proteolysis; meiotic spindle organization and biogenesis; meiosis I; chromosome segregation
Show more

Research Articles on ESPL1

1. Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESPL1 antibody

 Reference Product  PubMed Publications
 Pttg1 antibody  >39 publications with ESPL1 and Pttg1
 Rad21 antibody  >10 publications with ESPL1 and Rad21
 Plk1 antibody  >4 publications with ESPL1 and Plk1
 Smc3 antibody  >4 publications with ESPL1 and Smc3
 Rec8 antibody  >3 publications with ESPL1 and Rec8
 Cdc20 antibody  >2 publications with ESPL1 and Cdc20
 Stag1 antibody  >1 publications with ESPL1 and Stag1
 Bub1b antibody  >1 publications with ESPL1 and Bub1b

Pathways associated with anti-ESPL1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Signaling Pathway antibodies  Cell Cycle Signaling Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram

Diseases associated with anti-ESPL1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with ESPL1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with ESPL1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >4 publications with ESPL1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >3 publications with ESPL1 and Disease Models, Animal
 Infertility, Female Antibodies  >2 publications with ESPL1 and Infertility, Female
 Ovarian Diseases Antibodies  >1 publications with ESPL1 and Ovarian Diseases
 Lung Neoplasms Antibodies  >1 publications with ESPL1 and Lung Neoplasms
 Infertility, Male Antibodies  >1 publications with ESPL1 and Infertility, Male
 Carcinoma, Transitional Cell Antibodies  >1 publications with ESPL1 and Carcinoma, Transitional Cell
 Urinary Bladder Neoplasms Antibodies  >1 publications with ESPL1 and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-ESPL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Mammary Gland Antibodies  >4 publications with ESPL1 and Mammary Gland
 Bone Antibodies  >2 publications with ESPL1 and Bone
 Lung Antibodies  >2 publications with ESPL1 and Lung
 Bone Marrow Antibodies  >2 publications with ESPL1 and Bone Marrow
 Lymph Node Antibodies  >2 publications with ESPL1 and Lymph Node
 Kidney Antibodies  >2 publications with ESPL1 and Kidney
 Pancreas Antibodies  >1 publications with ESPL1 and Pancreas
 Thymus Antibodies  >1 publications with ESPL1 and Thymus
 Eye Antibodies  >1 publications with ESPL1 and Eye
 Brain Antibodies  >1 publications with ESPL1 and Brain
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